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Evaluation of Adiponectin, Resistin, IL-6, TNF-α in Obese and Non-obese Women with Polycystic Ovary Syndrome

查看全文 作　　者：Yu-xia [1]WANG;Wei-jie [2]ZHU 高影响力作者 机构地区：[1]Department of Obstetrics and Gynecology,the First Affiliated Hospital, Jinan University;[2]Institute of Reproductive Immunology, Jinan University高影响力机构 出　　处：《Journal of Reproduction and Contraception》索引2012年第23卷第4期,共8页高影响力期刊 基　　金：supported by the Fundamental Research Funds for the Central Universities,China(No.21612445) 摘　　要：Objective To evaluate possible clinical effects of adiponectin, resistin, IL-6, and TNF-α in obese and non-obese patients with polycystic ovary syndrome (PCOS). Methods Seventy selected PCOS patients were recruited for this study, and were divided into two groups based on their body mass index (BMI): 35 obese (BMI ≥ 25kg/m2 , group A), 35 non-obese (BMI<25kg/m2 , group B). In addition, 35 healthy non-obese women (BMI<25kg/m2 ) were enrolled as the control (group C). Serum levels of FSH, LH, T, glucose, insulin, adiponectin, resistin, IL-6, TNF-α were detected, and compared the differences of them among three groups. Results Blood glucose levels among three groups had no difference (P>0.05). Blood insulin level was significantly greater in group A than in group B or group C (P<0.05), and a significant difference existed between group B and group C (P<0.05). The ratio of glucose/insulin was significantly higher in group A than in group B or group C (P<0.05), and the ratio in group B was significantly higher than that in group C (P<0.05). Adiponectin level was significantly lower and resistin level was significantly higher in group A than in group B or group C (P<0.05). IL-6 level in group C was significantly lower than that in group A or group B (P<0.05), and significant difference was found between group A and group B (P<0.05). TNF-α level was a slight high in group B, whereas there was no statistical difference among three groups (P>0.05). Conclusion Disturbances of some metabolic and inflammatory adipokines could involve the pathogenesis of PCOS in both obese and non-obese women. Low-grade chronic inflammation might have negative effects on the development of PCOS in non-obese women. 关 键 词：多囊卵巢综合征 TNF-Α IL-6 脂联素 抵抗素 肥胖 妇女 血糖水平
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