A global perspective in asthma: from phenotype to endotype

查看全文 作　　者：Min [1,2]Xie;Sally E. [1]Wenzel

机构地区：[1]University of Pittsburgh Asthma Institute, Division of Pulmonary,Allergy and Critical Care Medicine, Department of Medicine,University of Pittsburgh, Pittsburgh PA 15213, USA;[2]Department of Respiratory and Critical Care Medicine, TongjiHospital, Tongji Medical College, Huazhong University of Scienceand Technology, Wuhan, Hubei 430030, China

出　　处：《Chinese Medical Journal》索引2013年第1期,共9页

基　　金：This work was supported by agrant from the National Natural Science Foundation of China(No.30900648) 摘　　要：Asthma affects about 300 million people worldwide,placing an enormous strain on health resources in many countries.Evidence is increasing that asthma is a complex condition with different underlying pathophysiologies.1 Scientists around the world have devoted much effort to unveiling this heterogeneity,from phenotyping initially focused on combinations of clinical characteristics,towards endotypes evolving which link pathophysiological mechanism to subtypes of asthma.2The identification of these endotypes,either by matching biology,genetics and therapeutic responses with clinically defined phenotypes or through unbiased genomic approaches,remains limited.3 Moving forward,ongoing studies that expand on these insights into the molecular signatures should enhance our ability to define the endotypes and lead to more targeted approaches to asthma therapy. 关键词：哮喘表型球性基因组学方法临床特征生理机制异质性科学家

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A global perspective in asthma: from phenotype to endotype

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