Selective micellar electrokinetic chromatographic method for simultaneous determination of some pharmaceutical binary mixtures containing non-steroidal anti-inflammatory drugs

查看全文 作　　者：Michael E.El-[1]Kommos;Niveen [1]A.Mohamed;Ahmed F.Abdel [1]Hakiem

机构地区：[1]Department of Pharmaceutical Analytical Chemistry,Faculty of Pharmacy,Assiut University

出　　处：《Journal of Pharmaceutical Analysis》索引2013年第3卷第1期,共8页

摘　　要：A simple and selective micellar electrokinetic chromatographic (MEKC) method has been developed for the analysis of five pharmaceutical binary mixtures containing three non-steroidal anti- inflammatory drugs (NSAIDs). The investigated mixtures were Ibuprofen (IP)-Paracetamol (PC), Ibuprofen (IP)-Chlorzoxazone (CZ), Ibuprofen (IP)-Methocarbamol (MC), Ketoprofen (KP)-Chlorzoxazone (CZ) and Diclofenac sodium (DS)-Lidocaine hydrochloride (LC). The separation was run for all mixtures using borate buffer (20 mM, pH 9) containing 15% (v/v) methanol and 100 mM sodium dodecyl sulphate (SDS) at 15 kV and the components were detected at 214 nm. Different factors affecting the electrophoretic mobility of the seven investigated drugs were studied and optimized. The method was validated according to international conference of harmonization (ICH) guidelines and United States pharmacopoeia (USP). The method was applied to the analysis of five pharmaceutical binary mixtures in their dosage forms. The results were compared with other reported high performance liquid chromatographic methods and no significant differences were observed. 关键词：二元混合物电动色谱法药品同时测定胶束消炎药酮基布洛芬非甾体类抗炎药

相关文献

参考文献（28）
引证文献（1）
耦合文献（0）

参考文献(28)

引证文献(1)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Selective micellar electrokinetic chromatographic method for simultaneous determination of some pharmaceutical binary mixtures containing non-steroidal anti-inflammatory drugs

参考文献(28)

引证文献(1)

用户提示