Genetic susceptibility to Candida infection: a new look at an old entity

查看全文 作　　者：Davide Firinu Maria Pisanu Bruno Piras Raffaella Meleddu Maria Maddalena Lorrai Paolo Emilio Manconi Stefano R. Del [1]Giacco

机构地区：[1]Department of Medical Sciences 'M. Aresu', Unit of InternalMedicine, Allergy and Clinical Immunology, University ofCagliari, Cagliari, Italy

出　　处：《Chinese Medical Journal》索引2013年第2期,共4页

摘　　要：The identification of the first molecular defect leading to Mendelian Susceptibility to Mycobacterial Disease (MSMD),1 a rare syndrome conferring predisposition to disease caused by weakly virulent mycobacteria (such as Mycobacterium bovis,Bacille Calmette Guérin vaccines and environmental mycobacteria),has led to a paradigm shift in the field of primary immunodeficiencies in the last two decades.The 'classic' patient with multiple immunologic abnormalities,conferring a broad susceptibility to multiple and recurrent infectious diseases caused by both weakly pathogenic and more virulent microorganisms,was the main Primary Immunodeficiency (PID) phenotype identified.Since 1996,mutations causing MSMD have been found in at least 6 genes related to interferon (IFN)-γ-mediated immunity.2 Intriguingly,this has opened the door to the identification of a molecular pathogenesis in patients affected by a narrow to extremely narrow susceptibility to bacterial,viral and fungal infections.3-7 These patients,more common than originally thought,are often otherwise healthy and are not prone to other unusually severe infections. 关键词：遗传易感性结核分枝杆菌念珠菌免疫缺陷传染性疾病面貌实体感染

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Genetic susceptibility to Candida infection: a new look at an old entity

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