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Changes in compressed neurons from dogs with acute and severe cauda equina constrictions following intrathecal injection of brain-derived neurotrophic factor-conjugated polymer nanoparticles

查看全文 作　　者：Junming [1]Tan;Jiangang [2]Shi;Guodong [2]Shi;Yanling [3]Liu;Xiaohong [3]Liu;Chaoyang [1]Wang;Dechun [1]Chen;Shunming [1]Xing;Lianbing [1]Shen;Lianshun [2]Jia;Xiaojian [2]Ye;Hailong [2]He;Jiashun [2]Li 高影响力作者 机构地区：[1]Center of Trauma Repair and Reconstruction of Chinese PLA and Department of Orthopedics of the 98th Hospital of Chinese PLA;[2]Department of Orthopedics,Changzheng Hospital,Second Military Medical University;[3]Department of Pathologic Laboratory of Chest Surgery,Changhai Hospital,Second Military Medical University高影响力机构 出　　处：《Neural Regeneration Research》索引2013年第8卷第3期,共11页高影响力期刊 基　　金：supported by grants from the Medical Scientific Fund and Intensive Research of Nanjing Military Area Command of Chinese PLA, No.Nan2007-13 and Nan 08Z003;the Medical Scientific Fund and Research of Chinese PLA during the 12th Five-Year Plan Period,No.CWS11J260 摘　　要：This study established a dog model of acute multiple cauda equina constriction by experimental constriction injury (48 hours) of the lumbosacral central processes in dorsal root ganglia neurons. The repair effect of intrathecal injection of brain-derived neurotrophic factor with 15 mg encapsulated biodegradable poly(lactide-co-glycolide) nanoparticles on this injury was then analyzed. Dorsal root ganglion cells (L7) of all experimental dogs were analyzed using hematoxylin-eosin staining and immunohistochemistry at 1, 2 and 4 weeks following model induction. Intrathecal injection of brain-derived neurotrophic factor can relieve degeneration and inflammation, and elevate the expression of brain-derived neurotrophic factor in sensory neurons of compressed dorsal root ganglion. Simultaneously, intrathecal injection of brain-derived neurotrophic factor obviously improved neurological function in the dog model of acute multiple cauda equina constriction. Results verified that sustained intraspinal delivery of brain-derived neurotrophic factor encapsulated in biodegradable nanoparticles promoted the repair of histomorphology and function of neurons within the dorsal root ganglia in dogs with acute and severe cauda equina syndrome. 关 键 词：脑源性神经营养因子 背根神经节神经元 聚合物纳米粒子 鞘内注射 实验犬 急性 收缩 压缩
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