Effect of scraping therapy on Interleukin-1 in serum of rats with lumbar disc herniation

查看全文 作　　者：Rongrong [1]Jiang;Guihua [1]Xu;Hua [1]Chen;Jie [1]Li;Tao [2]Yang;Yang [3]Guo

机构地区：[1]Nursing College, Nanjing University of Chinese Medicine;[2]Basic Medical College, Nanjing University of Chinese Medicine;[3]The First Clinical College, Nanjing University of Chinese Medicine

出　　处：《Journal of Traditional Chinese Medicine》索引2013年第33卷第1期,共5页

基　　金：Supported by Natural Science Foundation of University in Jiangsu Province (No. 11KJB360003) 摘　　要：OBJECTIVE:To explore the effect of scraping therapy on the Interleukin-1 (IL-1) levels of rats with lumbar disc herniation (LDH). METHODS: Fifty male rats were devided into a blank group (A), a sham operation group (B), a model group (C), a scraping group (D), and a drug group (E). The rats in the group B were treated with sham operation, and groups C, D and E were made into the LDH model by operation. After operation group C were treated with no interventions, D were given scraping and E were fed with azathioprine Then the IL-1 levels of different groups were detected by enzyme-linked immuno sorbent assay method. And the transplanted coccygeal vertebra discs were observed by pathological section. RESULTS: The IL-1 levels in the groups C, D, and E were significantly higher than those in the groups A and B (all P<0.01), which proved the operationwas successful.The IL-1 levels in the groups D and E at different periods had statistical significance (F= 414.158, P<0.01). The treatment periods and interventions have interation (F=46.613, P<0.01). Multiple comparison results showed that the IL-1 levels in the groups D and E was significantly lower than that in the group C (P<0.01), while the IL-1 levels between the groups D and E had no statistical significance (P>0.05). Moreover, pathological section indicated that immuno-inflammatory response was hardly found in coccygeal vertebra discs in the groups A and B, while local immuno-inflammatory responses of the groups D and E were much lighter than that of the group C. CONCLUSION: Scraping therapy could inhibit the immuno-inflammatory responses in the rats with LDH caused by transplantation of autologous nu cleus pulposus. 关键词：腰椎间盘突出症雄性大鼠白细胞介素-1 疗法酶联免疫吸附法血清 IL-1 炎症反应

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Effect of scraping therapy on Interleukin-1 in serum of rats with lumbar disc herniation

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