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Magnetic nanoparticle-based cancer therapy

查看全文 作  者:[1]余靓;[2]黄冬雁;Muhammad Zubair [1]Yousaf;[1]侯仰龙;[3]高松 高影响力作者 机构地区:[1]Department of Materials Science and Engineering,College of Engineering,Peking University;[2]Department of Otorhinolaryngology Head & Neck Surgery,Clinical Division of Surgery,Chinese PLA (People's Liberation Army) General Hospital;[3]College of Chemistry and Molecular Engineering,Peking University高影响力机构 出  处:《Chinese Physics B》索引2013年第22卷第2期,共13页高影响力期刊 基  金:Project supported by the National Natural Science Foundation of China (Grant Nos. 51125001,51172005,and 90922033);the Research Fellowship for International Young Scientists of the National Natural Science Foundation of China (Grant No. 51250110078);the Doctoral Program of the Education Ministry of China (Grant No. 20120001110078);PKU COE-Health Science Center Seed Fund 摘  要:Nanoparticles(NPs) with easily modified surfaces have been playing an important role in biomedicine.As cancer is one of the major causes of death,tremendous efforts have been devoted to advance the methods of cancer diagnosis and therapy.Recently,magnetic nanoparticles(MNPs) that are responsive to a magnetic field have shown great promise in cancer therapy.Compared with traditional cancer therapy,magnetic field triggered therapeutic approaches can treat cancer in an unconventional but more effective and safer way.In this review,we will discuss the recent progress in cancer therapies based on MNPs,mainly including magnetic hyperthermia,magnetic specific targeting,magnetically controlled drug delivery,magnetofection,and magnetic switches for controlling cell fate.Some recently developed strategies such as magnetic resonance imaging(MRI) monitoring cancer therapy and magnetic tissue engineering are also addressed. 关 键 词:磁性纳米粒子 癌症治疗 基础 磁共振成像 生物医学 表面改性 死亡原因 肿瘤治疗
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