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Biological Activity and Antibacterial Property of Nano-structured TiO_2 Coating Incorporated with Cu Prepared by Micro-arc Oxidation

查看全文 作　　者：Wei [1]Zhu;Zhenxiang [2]Zhang;Beibei [2]Gu;Junying [1]Sun;Lixian [2]Zhu 高影响力作者 机构地区：[1]Orthopedic Department,The First Affiliated Hospital of Soochow University;[2]Orthopedic Department,Orthopedic Department,The Affiliated Taizhou People's Hospital of Nantong University高影响力机构 出　　处：《Journal of Materials Science & Technology》索引2013年第29卷第3期,共8页高影响力期刊 基　　金：supported by the Shanghai Science and Technology R&D Fund(Nos.0952nm04400,07JC14057 and 08ZR1421600);the National Basic Research Fund(No. 2005CB623901);the National Natural Science Foundation of China(Nos.30700170,30973041 and 81271959) 摘　　要：Micro-arc oxidized Cu-incorporated TiO2 coatings(Cu—TiO2) were prepared in the Ca,P,Cu-containing electrolyte to obtain an implant material with superior biological activity and antibacterial property.The surface topography,phase,and element composition of the TiO2 and Cu—TiO2 coatings were characterized by scanning electron microscopy(SEM),X-ray diffraction(XRD),and energy-dispersive X-ray spectrometry (EDS),respectively.Staphylococcus aureus(S.aureus) was selected to evaluate the antibacterial property of the Cu—TiO2 coatings,whereas osteoblastic MG63 cells were cultured on the coatings to investigate the biological activity.The obtained results demonstrated that Cu element was successfully incorporated into the porous nano-structured TiO2 coatings,which did not alter apparently the surface topography and phase composition of the coatings as compared to the Cu-free TiO2 coatings.Moreover,the antibacterial studies suggested that the Cu-incorporated TiO2 coatings could significantly inhibit the adhesion of S.aureus.In addition,the in vitro biological evaluation displayed that the adhesion,proliferation and differentiation of MG63 cells on the Cu-incorporated coatings were enhanced as compared to those on the Cu-free coatings and Ti plates.In conclusion,the innovative Cu-incorporated nano-structured TiO2 coatings on Ti substrate with excellent antibacterial property and biological activity are promising candidates for orthopedic implant. 关 键 词：二氧化钛涂层 抗菌性能 生物活性 纳米结构 氧化铜 制备 注册 金黄色葡萄球菌
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