Antitumor effects of electrochemical treatment

查看全文 作　　者：Héctor Manuel Camué [1]Ciria;Maraelys Morales [2]González;Lisset Ortíz [2]Zamora;Luis Enrique Bergues [1]Cabrales;Gustavo Victoriano Sierra [3]González;Luciana Oliveira de [4]Oliveira;Rodrigo [4]Zanella;Antonio Carlos [5]Buzaid;Orlando [5]Parise;Luciana Macedo [6]Brito;Cesar Augusto Antunes [6]Teixeira;Marina das Neves [6]Gomes;Gleyce [6]Moreno;Venicio Feo da [6,7]Veiga;Marcos [8]Telló;Carla [6]Holandino

机构地区：[1]Research Department, National Centre of Applied Electromagnetism, Oriente University;[2]Pharmacy Department, Oriente University;[3]Finlay Institute, La lisa. La Habana, Cuba;[4]Veterinary Teaching Hospital, Federal University of Rio Grande do Sul. Porto Alegre;[5]Sírio e Libanês Hospital;[6]Faculty of Pharmacy, Medicine Department, Federal University of Rio de Janeiro;[7]Professor Paulo de Góes Institute of Microbiology, Federal University of Rio de Janeiro;[8]Pontifical Catholic University of Rio Grande do Sul. Porto Alegre

出　　处：《Chinese Journal of Cancer Research》索引2013年第25卷第2期,共12页

基　　金：supported by the Ministry of Superior Education, Republic of Cuba;by the Brazilian financial agencies (FAPERJ, CNPq and FUJB) 摘　　要：Electrochemical treatment is an alternative modality for tumor treatment based on the application of a low intensity direct electric current to the tumor tissue through two or more platinum electrodes placed within the tumor zone or in the surrounding areas. This treatment is noted for its great effectiveness, minimal invasiveness and local effect. Several studies have been conducted worldwide to evaluate the antitumoral effect of this therapy. In all these studies a variety of biochemical and physiological responses of tumors to the applied treatment have been obtained. By this reason, researchers have suggested various mechanisms to explain how direct electric current destroys tumor cells. Although, it is generally accepted this treatment induces electrolysis, electroosmosis and electroporation in tumoral tissues. However, action mechanism of this alternative modality on the tumor tissue is not well understood. Although the principle of Electrochemical treatment is simple, a standardized method is not yet available. The mechanism by which Electrochemical treatment affects tumor growth and survival may represent more complex process. The present work analyzes the latest and most important research done on the electrochemical treatment of tumors. We conclude with our point of view about the destruction mechanism features of this alternative therapy. Also, we suggest some mechanisms and strategies from the thermodynamic point of view for this therapy. In the area of Electrochemical treatment of cancer this tool has been exploited very little and much work remains to be done. Electrochemical treatment constitutes a good therapeutic option for patients that have failed the conventional oncology methods. 关键词：电化学治疗抗肿瘤作用破坏机制肿瘤组织生理生化反应肿瘤治疗电化学处理周边地区

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Antitumor effects of electrochemical treatment

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