Pancreatic neuroendocrine tumors: biology, diagnosis, and treatment

查看全文 作　　者：Cynthia [1]Ro;Wanxing [1]Chai;Victoria [1]E.Yu;Run [1]Yu

机构地区：[1]Cedars-Sinai Medical Center,Los Angeles, CA 90048, USA

出　　处：《Chinese Journal of Cancer》索引2013年第32卷第6期,共13页

摘　　要：Pancreatic neuroendocrine tumors (PNETs), a group of endocrine tumors arising in the pancreas, are among the most common neuroendocrine tumors. The genetic causes of familial and sporadic PNETs are somewhat understood, but their molecular pathogenesis remains unknown. Most PNETs are indolent but have malignant potential. The biological behavior of an individual PNET is unpredictable; higher tumor grade, lymph node and liver metastasis, and larger tumor size generally indicate a less favorable prognosis. Endocrine testing, imaging, and histological evidence are necessary to accurately diagnose PNETs. A 4-pronged aggressive treatment approach consisting of surgery, locoregional therapy, systemic therapy, and complication control has become popular in academic centers around the world. The optimal application of the multiple systemic therapeutic modalities is under development; efficacy, safety, availability, and cost should be considered when treating a specific patient. The clinical presentation, diagnosis, and treatment of specific types of PNETs and familial PNET syndromes, including the novel Mahvash disease, are summarized. 关键词：肿瘤生物学神经内分泌全身治疗胰腺诊断生物学行为发病机制学术中心

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Pancreatic neuroendocrine tumors: biology, diagnosis, and treatment

参考文献(160)

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耦合文献(53)

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