A multiple-labelling method for cells using Au nanoparticles with different shapes

查看全文 作　　者：ZHANG [1]Ke;FENG [2]JianTao;SUN [2]QuanMei;JIN [2]Lin;LI [2]Jing;WU [1]XiaoChun;HAN [2]Dong

机构地区：[1]Chinese Academy of Sciences Key Laboratory of Standardisation and Measurement for Nanotechnology, National Centre for Nanoscience and Technology;[2]Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Centre for Nanoscience and Technology

出　　处：《Chinese Science Bulletin》索引2013年第58卷第21期,共6页

基　　金：supported by the National Basic Research Program of China (2012CB933800 and 2011CB932802);the National Natural Science Foundation of China (21173056 and 21201041) 摘　　要：An important and difficult issue is simultaneously identifying the detailed locations of various molecules on the cell surface, as this identification requires a synergistic effect between more than one molecule in a living cell. Au nanoparticles (NPs) with different shapes can be readily recognised under low vacuum scanning electron microscopy (lvSEM). Anisotropic Au nanorods (NRs) possess unique surface plasmon resonance (SPR) properties, which can be further utilised for two photon luminescence (TPL) and other optical imaging techniques. In this paper, Au NRs and Au nanooctahedra (Au NOs) are introduced as biomarkers for ICAM-1 and Integrin β1. Combined with the advantages of lvSEM, this multiple-labelling method is a new method for studying the interactions between specific, functional molecules. 关键词：金纳米粒子细胞表面形状扫描电子显微镜标签表面等离激元 ICAM-1 自然保护区

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A multiple-labelling method for cells using Au nanoparticles with different shapes

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