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Effect of Linguizhugan decoction on hyperlipidemia rats with intermittent fasting

查看全文 作  者:Yubin [1]Yang;Jian [1]Qin;Bin [1]Ke;Junjie [1]Zhang;Lanying [1]Shi;Qiong [1]Li 高影响力作者 机构地区:[1]Traditional Chinese Medicine Department,First Affiliated Hospital of Sun Yat-Sen University高影响力机构 出  处:《Journal of Traditional Chinese Medicine》索引2013年第33卷第2期,共3页高影响力期刊 基  金:Supported by International Science and Technology Cooperation Program of Guangdong Province (No.2009B050700022) 摘  要:OBJECTIVE:To explore the effect of Linguizhugan decoction on hyperlipidemia rats with caloric restriction.METHODS:The hyperlipidemia model of rat was induced by high fat diet for 8 weeks.After the model was established,26 rats were randomly divided into 4 groups:the control group(n=6),the model group(n=6),the intermittent fasting(IF) group(n= 8),and the IF and herbal medicine(IFH) group(n= 6).IF group was applied intermittent fasting every other day.The IFH group was given Linguizhugan decoction every day and intermittent fasting every other day.Blood samples were taken at the end of 16 weeks,and serum ghrelin and lipid was tested.RESULTS:Serum ghrelin in the IF group significantly increased(P<0.01).Serum ghrelin in IFH group was lower than the IF group(P<0.05),but higher than the model group(P<0.01).CONCLUSION:Linguizhugan decoction may play a part in regulation of energy and appetite in hyperlipidemia rats with IF. 关 键 词:大鼠模型 高脂血症 间歇性 禁食 生长素释放肽 GHRELIN 热量限制 高脂饮食
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