How does the motor relearning program improve neurological function of brain ischemia monkeys?

查看全文 作　　者：Yong [1]Yin;Zhen [2]Gu;Lei [1]Pan;Lu [1]Gan;Dongdong [3]Qin;Bo [4]Yang;Jin [5]Guo;Xintian [3]Hu;Tinghua [6]Wang;Zhongtang [6]Feng

机构地区：[1]Department of Rehabilitation Medicine, Fourth Hospital of Kunming Medical University;[2]Department of Neurosurgery, Fourth Hospital of Kunming Medical University;[3]Kunming Institute of Zoology, Chinese Academy of Sciences;[4]Department of Nuclear Medicine, Fourth Hospital of Kunming Medical University;[5]Department of Pathology, Fourth Hospital of Kunming Medical University;[6]Institute of Neuroscience, Kunming Medical University

出　　处：《Neural Regeneration Research》索引2013年第8卷第16期,共10页

基　　金：supported by the Combined pecific Foundation of Department of Science and Technology of Yunnan Province and Kunming Medical University,No.2008CD037 摘　　要：The motor relearning program can significantly improve various functional disturbance induced by ischemic cerebrovascular diseases. However, its mechanism of action remains poorly understood. In injured brain tissues, glial fibrillary acidic protein and neurofilament protein changes can reflect the condition of injured neurons and astrocytes, while vascular endothelial growth factor and basic fibroblast growth factor changes can indicate angiogenesis. In the present study, we induced ischemic brain injury in the rhesus macaque by electrocoagulation of the M1 segment of the right middle cerebral artery. The motor relearning program was conducted for 60 days from the third day after model establishment. Immunohistochemistry and single-photon emission CT showed that the numbers of glial fibrillary acidic protein-, neurofilament protein-, vascular endothelial growth factor- and basic fibroblast growth factor-positive cells were significantly increased in the infarcted side compared with the contralateral hemisphere following the motor relearning program. Moreover, cerebral blood flow in the infarcted side was significantly improved. The clinical rating scale for stroke was used to assess neurological function changes in the rhesus macaque following the motor relearning program. Results showed that motor function was improved, and problems with consciousness, self-care ability and balance function were significantly ameliorated. These findings indicate that the motor relearning program significantly promoted neuronal regeneration, repair and angiogenesis in the surroundings of the infarcted hemisphere, and improve neurological function in the rhesus macaque following brain ischemia. 关键词：运动功能神经功能再学习脑缺血碱性成纤维细胞生长因子恒河猴胶质纤维酸性蛋白神经丝蛋白

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How does the motor relearning program improve neurological function of brain ischemia monkeys?

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