X-irradiation for inhibiting glial scar formation in injured spinal cord

查看全文 作　　者：Guangzhi [1]Ning;Renhui [2]Chen;Yulin [1]Li;Qiang [1]Wu;Qiuli [1]Wu;Yan [1]Li;Shiqing [1]Feng

机构地区：[1]Department of Orthopedics, Tanjin Medical University General Hospital;[2]Department of Orthopedics, Tianjin 4th Central Hospital

出　　处：《Neural Regeneration Research》索引2013年第8卷第17期,共8页

基　　金：supported by the National Natural Science Foundation of China, No. 81070982, 81201400;Tianjin Research Program of Application Foundation and Advanced Technology, No. 10JCZDJC18800, 13JCQNJC11100;the Research Foundation of Tianjin Health Bureau, No. 09kz104 摘　　要：X-irradiation has a beneficial effect in treating spinal cord injury. We supposed that X-irradiation could improve the microenvironment at the site of a spinal cord injury and inhibit glial scar formation. Thus, this study was designed to observe the effects of 8 Gy X-irradiation on the injury site at 6 hours and 2, 4, 7, and 14 days post injury, in terms of improvement in the microenvironment and hind limb motor function. Immunohistochemistry showed that the expression of macrophage marker ED-1 and the area with glial scar formation were reduced. In addition, the Basso, Beattie and Bresnahan score was higher at 7 days post injury relative to the other time points post injury. Results indicated that X-irradiation at a dose of 8 Gy can inhibit glial scar formation and alleviate the inflammatory reaction, thereby repairing spinal cord injury. X-irradiation at 7 days post spinal cord injury may be the best time window. 关键词：脊髓损伤照射瘢痕胶质损伤部位运动功能免疫组化细胞标记

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X-irradiation for inhibiting glial scar formation in injured spinal cord

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