Role and regulation of the forkhead transcription factors FOXO3a and FOXM1 in carcinogenesis and drug resistance

查看全文 作　　者：Ana [1]R.Gomes;Fung [1]Zhao;Eric [1]W.F.Lam

机构地区：[1]Department of Surgery and Cancer,Imperial College London,Hammersmith Hospital Campus

出　　处：《Chinese Journal of Cancer》索引2013年第32卷第7期,共6页

摘　　要：The FOXO3a and FOXM1 forkhead transcription factors are key players in cancer initiation,progression,and drug resistance.Recent research shows that FOXM1 is a direct transcriptional target of FOXO3a,a vital downstream effector of the PI3K-AKT-FOXO signaling cascade.In addition,FOXM1 and FOXO3a also antagonize each other's activity by competitively binding to the same target genes,which are involved in chemotherapeutic drug sensitivity and resistance.Understanding the role and regulation of the FOXO-FOXM1 axis will provide insight into chemotherapeutic drug action and resistance in patients,and help to identify novel therapeutic approaches as well as diagnostic and predictive biomarkers. 关键词：转录因子耐药性叉头致癌性化疗药物生物标志物竞争力敏感性

相关文献

参考文献（39）
引证文献（19）
耦合文献（0）

参考文献(39)

引证文献(19)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Role and regulation of the forkhead transcription factors FOXO3a and FOXM1 in carcinogenesis and drug resistance

参考文献(39)

引证文献(19)

用户提示