Duck egg drop syndrome virus:an emerging Tembusu-related flavivirus in China

查看全文 作　　者：LIU [1,2]PeiPei;LU [3]Hao;LI [4]Shuang;WU [1]Ying;George Fu [1,2,5,6]GAO;SU [4]JingLiang

机构地区：[1]CAS Key Laboratory of Pathogenic Microbiology and Immunology,Institute of Microbiology,Chinese Academy of Sciences;[2]University of Chinese Academy of Sciences;[3]Bureau of Life Sciences and Biotechnology,Chinese Academy of Sciences;[4]Key Laboratory of Animal Epidemiology and Zoonosis,Ministry of Agriculture,College of Veterinary Medicine,China Agricultural University;[5]National Institute for Viral Disease Control and Prevention,Chinese Center for Disease Control and Prevention;[6]Research Network of Immunity and Health,Beijing Institutes of Life Science,Chinese Academy of Sciences

出　　处：《Science China(Life Sciences)》索引2013年第56卷第8期,共10页

基　　金：supported by the National Basic Research Program of China,Ministry of Science and Technology of China (2011CB504703);National Natural Science Foundation of China (81021003);Gao George Fu is a leading principal investigator of the NSFC Innovative Research Group 摘　　要：Duck egg drop syndrome virus(DEDSV) is a newly emerging pathogenic flavivirus isolated from ducks in China.DEDSV infection mainly results in severe egg drop syndrome in domestic poultry,which leads to huge economic losses.Thus,the discovery of ways and means to combat DEDSV is urgent.Since 2010,a remarkable amount of progress concerning DEDSV research has been achieved.Here,we review current knowledge on the epidemiology,symptomatology,and pathology of DEDSV.A detailed dissection of the viral genome and polyprotein sequences,comparative analysis of viral antigenicity and the corresponding potential immunity against the virus are also summarized.Current findings indicate that DEDSV should be a distinct species from Tembusu virus.Moreover,the adaption of DEDSV in wildlife and its high homology to pathogenic flaviviruses(e.g.,West Nile virus,Japanese encephalitis virus,and dengue virus),illustrate its reemergence and potential to become a zoonotic pathogen that should not be overlooked.Detailed insight into the antigenicity and corresponding immunity against the virus is of clear significance for the development of vaccines and antiviral drugs specific for DEDSV. 关键词：减蛋综合征病毒鸭子中国抗病毒药物日本脑炎病毒西尼罗河病毒病毒基因组病毒分离

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Duck egg drop syndrome virus:an emerging Tembusu-related flavivirus in China

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