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Comparing gene expression profiles of Kashin-Beck and Keshan diseases occurring within the same endemic areas of China

查看全文 作　　者：WANG [1]Xi;WANG [1]Shuang;HE [1]ShuLan;ZHANG [1]Feng;TAN [1]WuHong;LEI [1]YanXia;YU [2]HanJie;LI [2]Zheng;NING [1]YuJie;XIANG [3]YouZhang;GUO [1]Xiong 高影响力作者 机构地区：[1]Faculty of Public Health, Medical College of Xi'an Jiaotong University, Key Laboratory of Environment and Gene Related Diseases of Ministry of Education, Key Laboratory of Trace Elements and Endemic Diseases of Ministry of Health;[2]National Engineering Research Center for Miniaturized Detection Systems, Northwest University;[3]Shandong Institute for Prevention & Treatment of Endemic Disease高影响力机构 出　　处：《Science China(Life Sciences)》索引2013年第56卷第9期,共7页高影响力期刊 基　　金：supported in part by the Key Scientific and Technological Innovation Special Projects of Shaanxi '13115' of China (2009ZDKG-79);the National Natural Science Foundation of China (30872192, 81273008) 摘　　要：In this study, differentially expressed genes in peripheral blood from patients with Kashin-Beck disease and Keshan disease were compared to further investigate the etiology and pathogenesis of both diseases, which occur in a common endemic area of China. Twenty Kashin-Beck disease patients and 12 healthy controls, and 16 Keshan disease patients and 16 healthy controls, were grouped into four pairs. Patients and controls were selected from common endemic areas for the two diseases. Total RNA was isolated from peripheral blood mononuclear cells from all patients and controls, and gene expression profiles analyzed by oligonucleotide microarrays. Sixteen genes differentially expressed in both Kashin-Beck disease and Keshan disease (versus controls) were identified, and comprised nine genes showing synchronous and seven asynchronous expression. The Comparative Toxicogenomics Database shows that expression and biological function of these genes can be affected by multiple environmental factors, including mycotoxin and selenium content, potential environmental risk factors for the two diseases. Thus, these shared differentially expressed genes may contribute to the distinct organ lesions, caused by common environmental risk factors of Kashin-Beck disease and Keshan disease. 关 键 词：基因表达谱 大骨节病 克山病 流行区 中国 外周血单个核细胞 差异表达基因 疾病流行
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