Synthesis of tetrazole containing 1,2,3-thiadiazole derivatives via U-4CR and their anti-TMV activity

查看全文 作　　者：Shou-Xin [1,2]Wanga;Zhen [2]Fang;Zhi-Jin [2]Fan;Dun [2]Wang;Yue-Dong [2]Li;Xiao-Tian [2]Ji;Xue-Wen [2]Hua;Yun [3]Huang;Tatiana [4]A.Kalinina;Vasiliy [4]A.Bakulev;Yury [3]Yu.Morzherin

机构地区：[1]School of Basic Sciences,Jining Medical University;[2]State Key Laboratory of Elemento-Organic Chemistry,Nankai University;[3]Department of Plant Pathology,Sichuan Agricultural University;[4]The Ural Federal University Named after the First President of Russia B.N.Yeltsin

出　　处：《Chinese Chemical Letters》索引2013年第24卷第10期,共4页

基　　金：funded in part by the NSF of Tianjin (No. 10JCZDJC17500);the National Key Project for Basic Research (No. 2010CB126105);National Key Technology Research and Development Program (No. 2011BAE06B02);the Foundation of Achievements Transformation and Application of Tianjin Agricultural Science and Technology (No. 201002250);Tianjin Key Technology Research and Development Program (No. 11ZCGYNC00100);The Commonweal Specialized Research Fund of China Agriculture (Nos. nyhyzx3-21, 201103016 and 201003029) 摘　　要：A series of novel tetrazole containing 1,2,3-thiadiazole derivatives were designed and synthesized via Ugi reaction. Their structures were confrmed by melting points, IR,1H NMR, and HRMS(ESI).Preliminary bioassay indicated that most target compounds exhibited very good direct anti-TMV activity at 100 μg/mL, which was equal to or higher than that of ribavirin. Among them, compounds 4b, 4c and 4i also showed equivalent protection effect to ribavirin in vivo at 100μg/mL. 关键词：抗烟草花叶病毒活性噻二唑衍生物反应合成利巴韦林 HRMS 活性测试保护效果化合物

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Synthesis of tetrazole containing 1,2,3-thiadiazole derivatives via U-4CR and their anti-TMV activity

参考文献(25)

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