Molecular Epidemiological Characteristics of Streptococcus pyogenes Strains Involved in an Outbreak of Scarlet Fever in China,2011

查看全文 作　　者：YOU Yuan [1]Hai;SONG Yan [2]Yan;YAN Xiao [1]Mei;WANG Hai [2]Bin;ZHANG Meng [3]Han;TAO Xiao [1]Xia;Li Lei [4]Lei;ZHANG Yu [1]Xin;JIANG Xi [4]Hong;ZHANG Bing [1]Hua;ZHOU [5]Hao;XIAO [1]Di;JIN Lian [4]Mei;FENG Zi [4]Jian;LUO Feng [2]Ji;ZHANG Jian [1]Zhong

机构地区：[1]Collabroative Innovation Center for Diagnosis Treatment of Infectious Disease,State Key Laboratory for Infectious Disease Prevention and Control,National Institute for Communicable Disease Control and Prevention;[2]Chaoyang District Center for Disease Control and Prevention Beijing;[3]Suzhou City Center for Disease Control and Prevention;[4]Office of Disease Control and Emergency Response,Chinese Center for Disease Control and Prevention;[5]Harbin Municipal Center for Disease Control and Prevention

出　　处：《Biomedical and Environmental Sciences》索引2013年第26卷第11期,共9页

基　　金：supported by a fund for China Mega-Project for Infectious Disease(2011ZX10004-001) 摘　　要：Objective To investigate molecular characterization of streptococcus pyogenes isolates involved in an outbreak of scarlet fever in China in 2011.Methods Seventy-four Streptococcal pyogenes involved in an outbreak of scarlet fever were isolated from pediatric patients in the areas with high incidence in China from May to August of 2011.Emm genotyping,pulsed-field gel electrophoresis (PFGE),superantigen (SAg) genes and antimicrobial susceptibility profiling were analyzed for these isolates.Results A total of 4 different emm types were identified.Emm12 was the most prevalent type which contained four predominating PFGE patterns corresponding to four different virulence and superantigen profiles.Emm12 (79.7%) and emml (14.9%) accounted for approximately 94%of all the isolates.The speA gene was all negative in emm12 isolates and positive in emml isolates.All strains were resistant to erythromycin,and 89.4%of them were resistant to erythromycin,tracycline,and clindamycin simultaneously.Conclusion Several highly diversified clones with a high macrolide resistance rate comprise a predominant proportion of circulating strains,though no new emm type was found in this outbreak.The data provide a baseline for further surveillance of scarlet fever,which may contribute to the explanation of the outbreak and development of a GAS vaccine in China. 关键词：分子鉴定化脓性流行病学特征链球菌菌株爆发中国脉冲场凝胶电泳

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Molecular Epidemiological Characteristics of Streptococcus pyogenes Strains Involved in an Outbreak of Scarlet Fever in China,2011

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