Persistence of VRC01-resistant HIV-1 during antiretroviral therapy

查看全文 作　　者：GUO [1]DongXing;SHI [2]XuanLing;SONG [2]DingKa;ZHANG [2]LinQi

机构地区：[1]Beijing Tropical Medicine Research Institute, Beijing Friendship Hospital, Capital Medical University;[2]Comprehensive AIDS Research Center and Research Center for Public Health, School of Medicine, Tsinghua University

出　　处：《Science China(Life Sciences)》索引2014年第57卷第1期,共9页

基　　金：supported by the National Grand Program on Key Infectious Disease Control(2012ZX10001-006,2012ZX10001-009 and 2012ZX10001-003);the National Outstanding Youth Award(30825035);the National Natural Science Foundation of China(81101236);the Tsinghua University Initiative Scientific Research Program 摘　　要：VRC01,a broadly neutralizing monoclonal antibody(bnmAb),can neutralize a diverse array of HIV-1 isolates by mimicking CD4 binding to the envelope glycoprotein gp120.We have previously demonstrated the presence of VRC01-resistant strains in an HIV-1 infected patient during antiretroviral therapy.Here,we report follow-up studies of two subsequent samples from the same patient.With genetic and phenotypic analysis of over 70 full-length molecular clones of the HIV-1 envelope,we show that VRC01-resistant HIV-1 continued to exist and change in its proportion of the infecting virus during treatment with a highly active antiretroviral therapy.Consistent with our previous observation,the resistant phenotype was associated with a single asparagine residue at position 460(N460),a potential N-linked glycosylation site in the V5 region.The persistence and continuing evolution of VRC01-resistant HIV-1 in vivo presents a great challenge to our future preventative and therapeutic interventions based on VRC01. 关键词：HIV-1 逆转录病毒耐药菌株持久性治疗单克隆抗体包膜糖蛋白表型分析

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Persistence of VRC01-resistant HIV-1 during antiretroviral therapy

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