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Expression of CDC42 in cervical squamous cell carcinoma and its correlation with clinicopathologic characteristics

查看全文 作　　者：Ding [1]Ma;Yuan [1]Cheng;Youyi [2]Zhang;Yanli [1]Guo;Zijian [2]Li;Geng [1]Li 高影响力作者 机构地区：[1]Department of Gynecology and Obstetrics,Peking University Third Hospital;[2]Institute of Vascular Medicine,Peking University Third Hospital and Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptide,Ministry of Health高影响力机构 出　　处：《Chinese Journal of Cancer Research》索引2013年第25卷第6期,共6页高影响力期刊 基　　金：supported by the National Natural Science Foundation of China(No.11072006,No.10772007 and No.81070078);National Basic Research Program of China(973 Program,2013CB933702) 摘　　要：Objective:The high expression of cell division cycle 42 protein(CDC42)may be involved in the occurrence and progression of several tumors.However,the expression and function of CDC42 in cervical squamous cell carcinoma remains unclear.This study aimed to investigate the expression of CDC42 in cervical squamous cell carcinoma and its correlation with clinicopathologic characteristics.Methods:The expression of CDC42 in 162 cervical squamous cell carcinoma tissue samples and 33 normal cervical tissue samples was investigated by immunohistochemistry.The CDC42 mRNA expression was detected by reverse transcription-polymerase chain reaction(RT-PCR).Results:ThecervicalsquamouscellcarcinomagroupshowedasignificantlyhigherCDC42positiverate,compared to the normal cervical tissues(P<0.05).Furthermore,the tissues of stage II-IV carcinoma patients showed higher CDC42 expression levels compared to stage I patients(P=0.05).In addition,the expression of CDC42 was not correlated to age of patients,differentiation degree of cancer cells,or lymph node metastasis(P>0.05).Furthermore,compare with normal cervical tissues,the CDC42 mRNAexpressionincervicalcancerhadnosignificantdifference.Conclusions:CDC42 was up-regulated at protein level,but not mRNA level,in cervical squamous cell carcinoma.The high expression of CDC42 was correlated to the clinical stage of the patients,indicating that CDC42 might contribute to the progression of cervical squamous cell carcinoma. 关 键 词：鳞状细胞癌 病理特征 宫颈 临床 MRNA水平 RT-PCR 聚合酶链反应 肿瘤细胞
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