Interferon-c and interleukin-4 detected in serum and saliva from patients with oral lichen planus

查看全文 作　　者：Wen-Zhao [1,2,3]Liu;Ming-Jing [3]He;Long [3]Long;Dong-Liang [3]Mu;Ming-Shu [3]Xu;Xue [3]Xing;Xin [3]Zeng;Ga [3]Liao;Hong-Xia [3]Dan;Qian-Ming [3]Chen

机构地区：[1]College of Stomatology, Chongqing Medical University;[2]Chongqing Research Center for Oral Diseases and Biomedical Science;[3]State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University

出　　处：《International Journal of Oral Science》索引2014年第6卷第1期,共5页

基　　金：supported by grants from the National Natural Science Foundation of China (No. 30930100, 81072218, 81200791, 81321002 and 81300882);the Doctoral Program of the Ministry of Education of China (No. 20110181110055 and 20120181120011);Natural Science Foundation of Chongqing (No. cstc2013jcyjA10042) 摘　　要：Our previous salivary study had demonstrated an apparent T helper 2(Th2)-predominance in saliva of oral lichen planus(OLP) patients and suggested a potential of salivary interleukin-4(IL-4) as a biomarker for monitoring disease severity. To further determine the consistency of Th1/Th2 bias of OLP, this study investigated the expression profile of interferon-c(IFN-c) and IL-4 in serum and the relationship of the serum levels of these cytokines with their saliva partners. Sixty ethnic Chinese patients with OLP(40 of the erythematous/ulcerative form and 20 of the reticular form) were recruited for this study, with 40 age–sex-matched healthy volunteers as control group. IFN-c and IL-4 levels in serum and paired saliva samples were screened by enzyme-linked immunosorbent assay. OLP patient showed a low-level IFN-c but high-level IL-4 expression profile in both serum and saliva, with a lower IFN-c/IL-4 ratio. Serum IL-4 level in the erythematous/ulcerative group was significantly higher than that in the reticular group. Serum levels of IFN-c and IL-4 were significantly and positively correlated with their saliva partners. These results provided more evidence for Th2 cytokinepredominant immune imbalance in OLP, as well as the potential of IL-4 as the biomarker for monitoring severity of OLP. 关键词：白细胞介素4 唾液腺干扰素血清患者酶联免疫吸附测定法苔藓扁平

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Interferon-c and interleukin-4 detected in serum and saliva from patients with oral lichen planus

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