Ingestion of Lactobacillus strain reduces anxiety and improves cognitive function in the hyperammonemia rat

查看全文 作　　者：LUO [1,2]Jia;WANG [1]Tao;LIANG [1,2]Shan;HU [1]Xu;LI [1,2]Wei;JIN [1]Feng

机构地区：[1]Key Laboratory of Mental Health,Institute of Psychology,Chinese Academy of Sciences;[2]University of Chinese Academy of Sciences

出　　处：《Science China(Life Sciences)》索引2014年第57卷第3期,共9页

基　　金：supported by NS Bio Japan;NS Health Biotechnology Beijing 摘　　要：Evidence suggests that the hyperammonemia(HA)-induced neuroinflammation and alterations in the serotonin(5-HT)system may contribute to cognitive decline and anxiety disorder during hepatic encephalopathy(HE).Probiotics that maintain immune system homeostasis and regulate the 5-HT system may be potential treatment for HA-mediated neurological disorders in HE.In this study,we tested the efficacy of probiotic Lactobacillus helveticus strain NS8 in preventing cognitive decline and anxiety-like behavior in HA rats.Chronic HA was induced by intraperitoneal injection of ammonium acetate for four weeks in male Sprague-Dawley rats.HA rats were then given Lactobacillus helveticus strain NS8(109 CFU mL?1)in drinking water as a daily supplementation.The Morris water maze task assessed cognitive function,and the elevated plus maze test evaluated anxiety-like behavior.Neuroinflammation was assessed by measuring the inflammatory markers:inducible nitric oxide synthase,prostaglandin E2,and interleukin-1βin the brain.5-HT system activity was evaluated by measuring 5-HT and its metabolite,5-HIAA,and the 5-HT precursor,tryptophan.Probiotic treatment of HA rats significantly reduced the level of inflammatory markers,decreased 5-HT metabolism,restored cognitive function and improved anxiety-like behavior.These results indicate that probiotic L.helveticus strain NS8 is beneficial for the treatment of cognitive decline and anxiety-like behavior in HA rats. 关键词：SD大鼠认知功能焦虑症色氨酸 MORRIS水迷宫血症神经系统疾病乳酸菌

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Ingestion of Lactobacillus strain reduces anxiety and improves cognitive function in the hyperammonemia rat

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