Shuganjieyu capsule increases neurotrophic factor expression in a rat model of depression

查看全文 作　　者：Jinhua [1,2]Fu;Yingjin [3]Zhang;Renrong [1]Wu;Yingjun [4]Zheng;Xianghui [1]Zhang;Mei [2]Yang;Jingping [1]Zhao;Yong [1]Liu

机构地区：[1]Mental Health Institute of the Second Xiangya Hospital,Key Laboratory of Psychiatry and Mental Health of Hunan Province,Central South University;[2]Department of Psychiatry, Brain Hospital of Hunan Province;[3]Laboratory of Ethnopharmacology, Institute of Integrated Traditional Medicine and Western Medicine, the Second Xiangya Hospital, Central South University;[4]Guangzhou Brain Hospital, Affiliated Hospital of Guangzhou Medical College

出　　处：《Neural Regeneration Research》索引2014年第9卷第5期,共9页

基　　金：supported by the National Natural Science Foundation of China,No.81071093,81171268 摘　　要：Shuganjieyu capsule has been approved for clinical treatment by the State Food and Drug Administration of China since 2008. In the clinic, Shuganjieyu capsule is often used to treat mild to moderate depression. In the rat model of depression established in this study, Shuganjieyu capsule was administered intragastrically daily before stress. Behavioral results confirmed that depressive symptoms lessened after treatment with high-dose(150 mg/kg) Shuganjieyu capsule. Immunohistochemistry results showed that high-dose Shuganjieyu capsule significantly increased phosphorylation levels of phosphorylation cyclic adenosine monophosphate response element binding protein and brain-derived neurotrophic factor expression in the medial prefrontal cortex and hippocampal CA3 area. Overall, our results suggest that in rats, Shuganjieyu capsule effectively reverses depressive-like behaviors by increasing expression levels of neurotrophic factors in the brain. 关键词：神经营养因子大鼠模型抑郁症因子表胶囊环磷酸腺苷临床治疗食品药品监督

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Shuganjieyu capsule increases neurotrophic factor expression in a rat model of depression

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