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Effect of externally applied Jidesheng anti-venom on skin and soft-tissue necrosis after Chinese cobra bite: a retrospective study

查看全文 作  者:Quanfang [1]Chen;Wei [2]Wang;Qibin [2]Li;Yulong [2]Bai;Xiaoying [1]Zou;Yanbin [1]Wu 高影响力作者 机构地区:[1]Institute of Respiratory Diseases,the First Affiliated Hospital of Guangxi Medical University;[2]Department of Emergency,the First Affiliated Hospital of Guangxi Medical University高影响力机构 出  处:《Journal of Traditional Chinese Medicine》索引2014年第34卷第2期,共5页高影响力期刊 基  金:Supported by Guangxi Natural Science Foundation (No.2012GXNSFAA276011 and No.2013GXNSFBA019163);Youth Science Foundation of Guangxi Medical University (No.GXMUYSF201216) 摘  要:OBJECTIVE: To evaluate the effects of Jidesheng anti-venom used externally for skin and soft-tissue necrosis from Chinese cobra bite.METHODS: A retrospective review was performed according to the clinical data recorded from January 2002 to December 2012. A total of 126 patients(116 females and 10 males) with skin and soft-tissue necrosis due to Chinese cobra bite were divided into two groups. The control group was treated externally with 40% glyceride magnesium sulfate(n=52), and the treatment group was given Jidesheng anti-venom externally(n=74). The data collected included maximum local necrotic area of skin and soft tissues, de-tumescence time, healing time,and skin-grafting rate.RESULTS: There were no significant differences in gender, age, and disease condition between the control and treatment groups(P>0.05). No statistically significant difference was found in de-tumescence time between the two groups(P>0.05). The maximum local necrotic area of skin and soft tissues was(19.9 ± 7.3) cm2in the treatment group,while it was(23.3±6.4) cm2in the control group.The healing time of the treatment group was shorter than that of the control group [(32.1 ± 3.7) vs(34.4±4.5) days)] The skin-grafting rate in the treatment group was lower than that of the control group(10.81% vs 25.00%). There were statistically significant differences in maximum local necrotic area of skin and soft tissues, healing time, and skin-grafting rate between the control and treatment groups(all P<0.05).CONCLUSION: External application of Jidesheng anti-venom may help to promote wound healing and reduce the skin-grafting rate in cases of skin and soft-tissue necrosis due to Chinese cobra bite. 关 键 词:皮肤移植 组织坏死 眼镜蛇 中国 蛇毒 伤口愈合 对照组 时间比
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