Identification of EGF as an Important Regulator for Promoting CYP3A4 Expression in Human Embryonic Stem Cell-Derived Hepatocytes Using TALEN-Based Gene Targeting

查看全文 作　　者：Ming YinaCollege of Veterinary Medicine; Jilin University;Huan [1]Yang;Xiaohua [1]Su;Ziyi [2]Li;Zhanpeng [2]Yue;Xueming [2]Zhang;Da [1]Sun;Yan [1]Shi;Dexue [2,3]Li

机构地区：[1]Shenzhen Stem Cell Engineering Laboratory, Key Laboratory of ChemicalGenomics, Peking University Shenzhen Graduate School;[2]College of Veterinary Medicine, Jilin University;[3]Academy of Military Medical Sciences

出　　处：《Journal of Genetics and Genomics》索引2014年第41卷第6期,共4页

基　　金：supported by the International Science & Technology Cooperation Program of China (No. 2013DFG30680);the National Major Science and Technology Project for Infectious Diseases of China (No. 2012ZX10004503) 摘　　要：Functional human hepatocytes are one of the most significant tools for studying drug absorption,distribution,metabolism and excretion/toxicity (ADME/Tox),especially for applications in preclinical drug development (Sahi et al.,2010;Godoy et al.,2013).They provide the closest in vitro model to the human liver and the only model that mimics the drug metabolic profiles found in vivo.However,these cells lose their metabolic function rapidly and dramatically during the in vitro culture process,which largely hinders their wider application in drug development (Sahi et al.,2010;Godoy et al.,2013).To overcome this obstacle,it is important to regulate the activities of key genes which are responsible for the detoxification metabolic function of human hepatocytes. 关键词：人肝细胞基因打靶表皮生长因子细胞来源人类胚胎药物开发鉴定代谢特征

相关文献

参考文献（17）
引证文献（2）
耦合文献（21）

参考文献(17)

引证文献(2)

耦合文献(21)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Identification of EGF as an Important Regulator for Promoting CYP3A4 Expression in Human Embryonic Stem Cell-Derived Hepatocytes Using TALEN-Based Gene Targeting

参考文献(17)

引证文献(2)

耦合文献(21)

用户提示