DIFFERENTIAL ROLES OF SPINAL CYCLOOXYGENASE (COX)-2 IN DEVELOPMENT OF PERSISTENT SPONTANEOUS NOCICEPTION AND HYPERALGESIA INDUCED BY SUBCUTANEOUS BEE VENOM INJECTION IN THE CONSCIOUS RAT

查看全文 作　　者：Zhen LI and Jun CHEN Department of Anatomy and K.K.Leung Brain Research Centre, The Fourth Military Medical University, Xi’an, 710032 出　　处：《神经解剖学杂志》索引2001年第17卷第B07期,共1页 摘　　要：Aim: To study the roles of spinal cyclooxygenase (COX) -2 in the development of persistent spontaneous nociception and mechanical and thermal hyperalgesia induced by subcutaneous(s.c.) bee venom injection, the effects of intrathecal (i.t.) administration of a selective COX-2 inhibitor, etodolac was evaluated in the conscious rat. Methods: Chronic intrathecal (i.t.) catheterization was performed and effects of i.t. pre-and post-application 关 键 词：大白鼠 脊髓环氧化酶2 持续性自发性损伤感受 痛觉过敏 蜂毒皮下注射