Resveratrol reduces intracellular reactive oxygen species levels by inducing autophagy through the AMPK-mTOR pathway

查看全文 作　　者：Jun [1,2,3]Song;Yeping [1]Huang;Wenjian [4]Zheng;Jing [1]Yan;Min [5]Cheng;Ruxing [2]Zhao;Li [2]Chen;Cheng [1]Hu;Weiping [1]Jia

机构地区：[1]Shanghai Diabetes Institute,Shanghai Key Laboratory of Diabetes Mellitus,Shanghai Key Clinical Center for Metabolic Diseases,Shanghai Jiao Tong University Affiliated Sixth People's Hospital,Shanghai 200233,China;[2]Department of Endocrinology,Qilu Hospital of Shandong University,Jinan 250012,China;[3]Department of Endocrinology,Shanghai East Hospital,Tongffi University School of Medicine,Shanghai 200120,China;[4]Department of Geriatrics,Qingdao Haici Medical Treatment Group,Qingdao 266000,China;[5]Huangdao Disease Prevention and Control Center,Qingdao 266555,China

出　　处：《Frontiers of Medicine》索引2018年第12卷第6期,共10页

基　　金：outstanding young scientist research grant in Shandong Province (No.2013BSE27128); National Natural Science Foundation of China (No.81370943); China Postdoctoral Science Foundation (No.2015M580334);Shanghai Municipal Health and Family Planning Commission Project (No.20134189). 摘　　要：Oxidative stress induced by free fatty acid aggravates endothelial injury,which leads to diabeti cardiovascular complications.Reduction of intracellular oxidative stress may attenuate these pathogeni processes.The dietary polyphenol resveratrol reportedly exerts potential protective effects against endothelia injury.This study determined whether resveratrol can reduce the palmitic acid (PA)-induced generation o reactive oxygen species (ROS)and further explored the underlying molecular mechanisms.We found tha resveratrol significantly reduced the PA-induced endothelial ROS levels in human aortic endothelial cells Resveratrol also induced endothelial cell autophagy,which mediated the effect of resveratrol on ROS reduction Resveratrol stimulated autophagy via the AMP-activated protein kinase (AMPK)-mTOR pathway.Taketogether,these data suggest that resveratrol prevents PA-induced intracellular ROS by autophagy regulation via the AMPK-mTOR pathway.Thus,the induction of autophagy by resveratrol may provide a novel therapeuti candidate for cardioprotection in metabolic syndrome. 关键词：RESVERATROL REACTIVE oxygen species AMPK mTOR AUTOPHAGY

相关文献

参考文献（32）
引证文献（11）
耦合文献（0）

参考文献(32)

引证文献(11)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Resveratrol reduces intracellular reactive oxygen species levels by inducing autophagy through the AMPK-mTOR pathway

参考文献(32)

引证文献(11)

用户提示