Blood-testis barrier and spermatogenesis: lessons From genetically-modified mice

查看全文 作　　者：Xiao-Hua [1]Jiang;Ihtisham [1]Bukhari;Wei [1]Zheng;Shi [1]Yin;Zheng [1]Wang;Howard J [1,2]Cooke;Qing-Hua [1,3]Shi 机构地区：[1]Hefei National Laboratory for Physical Sciences at Microscale, School of Life Sciences, University of Science and Technology of China, Hefei, China;[2]Medical Research Council, Human Genetics Unit and Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom;[3]Institute of Physics, Chinese Academy of Sciences, Hefei, China. 出　　处：《Asian Journal of Andrology》索引2014年第16卷第4期,共9页 基　　金：This work was supported by the National Basic Research Program (Nos. 2013CB947900, 2013CB945502 and 2014CB943101) of China (973), by grants from National Natural Science Foundation of China (No. 31371519) and the Knowledge Innovation Program of the Chinese Academy of Sciences (No. KSCX2-EW-R-07). 摘　　要：血睾丸障碍(BTB ) 在它在生精的试管为 meiotic 和 postmeiotic 细菌房间的发展和成熟创造唯一的微型环境的睾丸在邻近的 Sertoli 房间之间被发现。它是复合 proteinous 结构,包括紧密的连接(TJ ) 的房间连接的几种类型镇静,粘附连接和差距连接(GJ ) 。一些 junctional 蛋白质作为 BTB 的结构的蛋白质工作,一些有规章的角色。删除或编码这些蛋白质的基因的功能的 silencing 可以破坏 BTB,它可以引起到 meiotic 和 postmeiotic 房间的免疫学的或另外的损坏并且最终导致 spermatogenic 拘捕和不孕。在这评论,我们将在 BTB 结构上总结调查结果并且从遗传上修改的老鼠模型工作并且讨论未来观点。 关 键 词：转基因小鼠模型 屏障 精子 结构蛋白 生殖细胞 减数分裂 细胞连接 曲细精管