Green tea polyphenols protect spinal cord neurons against hydrogen peroxide-induced oxidative stress

查看全文 作　　者：Jianbo [1]Zhao;Shiqiang [1]Fang;Yajiang [1]Yuan;Zhanpeng [1]Guo;Jinhao [1]Zeng;Yue [1]Guo;Peifu [2]Tang;Xifan [1]Mei

机构地区：[1]Vertebral Column Ward,Department of Orthopedics,First Affiliated Hospital of Liaoning Medical University;[2]Department of Orthopedics,General Hospital of People’s Liberation Army

出　　处：《Neural Regeneration Research》索引2014年第9卷第14期,共7页

基　　金：financially supported by the National Natural Science Foundation of China,No.81171799;China Postdoctoral Science Foundation,No.2013T60948 摘　　要：Green tea polyphenols are strong antioxidants and can reduce free radical damage. To investigate their neuroprotective potential, we induced oxidative damage in spinal cord neurons using hydrogen peroxide, and applied different concentrations(50–200 μg/mL) of green tea polyphenol to the cell medium for 24 hours. Measurements of superoxide dismutase activity, malondialdehyde content, and expression of apoptosis-related genes and proteins revealed that green tea polyphenol effectively alleviated oxidative stress. Our results indicate that green tea polyphenols play a protective role in spinal cord neurons under oxidative stress. 关键词：脊髓神经元绿茶多酚氧化应激过氧化氢诱导超氧化物歧化酶活性细胞培养基丙二醛含量

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Green tea polyphenols protect spinal cord neurons against hydrogen peroxide-induced oxidative stress

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