Carboxypeptidase E (NF-α1):a new trophic factor in neuroprotection

查看全文 作　　者：Yong [1]Cheng;Niamh [1]X.Cawley;Y.Peng [1]Loh

机构地区：[1]Section on Cellular Neurobiology,Program on Developmental Neuroscience,Eunice Kennedy Shriver National Institute of Child Health and Human Development,National Institutes of Health Bethesda,MD 20892,USA

出　　处：《Neuroscience Bulletin》索引2014年第30卷第4期,共5页

基　　金：supported by the Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development,National Institutes of Health,Bethesda,MD,USA 摘　　要：Carboxypeptidase E(CPE) is a prohormone-processing enzyme and sorting receptor that functions intracellularly.However, recent studies have demonstrated that CPE acts as a trophic factor extracellularly to up-regulate the expression of a pro-survival gene.This mini-review summarizes the roles of CPE in neuroprotection and the implications for neurodegenerative diseases. 关键词：神经退行性疾病保护因子羧肽酶营养 CPE 神经保护细胞内体功能

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Carboxypeptidase E (NF-α1):a new trophic factor in neuroprotection

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