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Analgesis and Wound Healing Effect of Chitosan and Carboxymethyl Chitosan on Scalded Rats

查看全文 作　　者：HUANG [1]Shuya;HAN [1]Baoqin;SHAO [1]Kai;YU [1]Miao;LIU [1]Wanshun 高影响力作者 机构地区：[1]College of Marine Life Sciences, Ocean University of China高影响力机构 出　　处：《Journal of Ocean University of China》索引2014年第13卷第5期,共5页高影响力期刊 基　　金：supported by National High-Tech R&D Program of China (863 Program, 2014AA093605) 摘　　要：Analgesis and wound healing effect of chitosan and carboxymethyl chitosan on scalded rats were investigated. A II degree scald model was established in rats, which was subsequently treated with chitosan and carboxymethyl chitosan solution, respectively. The concentration of bradykinin and 5-hydroxytryptophan was detected by assaying enzyme-linked immunosorbent. Healing condition was observed and pathological sections were made to determine the healing effect of chitosan and carboxymethyl chitosan. Results showed that the concentration of bradykinin and 5-hydroxytryptophan peaked at the third hour post-wound in all groups, while the concentration of hydroxyproline peaked at the seventh day post-wound in both chitosan and carboxymethyl chitosan group. The concentration of bradykinin and 5-hydroxytryptophan of carboxymethyl chitosan group was significantly lower than that of control(P < 0.05), while that of chitosan group was similar to that of control(P > 0.05). These findings indicated that carboxymethyl chitosan reduced the concentration of algogenic substances, resulting in analgesia. During the whole recovery process, the hydroxyproline concentration in chitosan and carboxymethyl chitosan group on day 3 and 7 was significantly higher than that of control(P < 0.01); however the significance of such a highness decreased on day 14(P < 0.05). These findings indicated that chitosan and carboxymethyl chitosan accelerated tissue repair. Meanwhile, chitosan performed better in healing than carboxymethyl chitosan in both decrustation and healing time. In conclusion, carboxymethyl chitosan showed significant analgesis and wound-healing promotion effect, but chitosan only showed wound-healing promotion effect. 关 键 词：羧甲基壳聚糖 创面愈合 镇痛 烫伤 大鼠 伤口愈合 酶联免疫检测 脱乙酰壳多糖
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