Crystal structure of the YTH domain of YTHDF2 reveals mechanism for recognition of N6-methyladenosine

查看全文 作　　者：Tingting [1]Zhu;Ian A [2]Roundtree;Ping [1]Wang;Xiao [3,4]Wang;Li [1]Wang;Chang [1]Sun;Yuan [1]Tian;Jie [1]Li;Chuan [3,4]He;Yanhui [1]Xu

机构地区：[1]Fudan University Shanghai Cancer Center, Department of Oncology; and Institute of Biomedical Sciences and School of Basic Medical Sciences, Shanghai Medical College of Fudan University, Shanghai 200032, China;[2]Medical Scientist Training Program and Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, 1L 60637, USA;[3]Department of Chemistry and Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL 60637, USA;[4]Howard Hughes Medical Institute, The University of Chicago, Chicago, IL 60637, USA

出　　处：《Cell Research》索引2014年第24卷第12期,共4页

基　　金：We thank staff members ofbeamline BL17U at SSRF (Shanghai Synchrotron Radiation Facility, China) for their assistance in data collection, and Mr Lei Zhang and staff members of Biomedical Core Facility in Fudan University for their help on biochemical analyses. We thank Dr Jinbiao Ma for the help on synthesis of m6A-RNA. This work was supported by grants from the National Basic Research Program of China (2011CB965300), the National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program" of China (2014ZX09507-002), the National Natural Science Foundation of China (U1432242, 91419301, 31270779 and 31030019), the Basic Research Project of Shanghai Science and Technology Commission (12JC 1402700), and the "Shu Guang" project (11SG06) supported by Shanghai Municipal Education Commission and Shanghai Education Development Foundation. 关键词：晶体结构 mRNA 识别机制核糖体RNA 非编码RNA 信使RNA 转移RNA

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Crystal structure of the YTH domain of YTHDF2 reveals mechanism for recognition of N6-methyladenosine

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