Scar-modulating treatments for central nervous system injury

查看全文 作　　者：Dingding [1]Shen;Xiaodong [1]Wang;Xiaosong [1]Gu

机构地区：[1]Jiangsu Key Laboratory of Neuroregeneration,Nantong University

出　　处：《Neuroscience Bulletin》索引2014年第30卷第6期,共18页

基　　金：supported by grants from the National Basic Research Development Program (973 Program) of China (2014CB542202);National High-Technology Research Program (863 Program) of China (2012AA020502);the National Natural Science Foundation of China (81130080);a Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions,Jiangsu Province,China 摘　　要：Traumatic injury to the adult mammalian central nervous system(CNS) leads to complex cellular responses. Among them, the scar tissue formed is generally recognized as a major obstacle to CNS repair, both by the production of inhibitory molecules and by the physical impedance of axon regrowth. Therefore, scar-modulating treatments have become a leading therapeutic intervention for CNS injury. To date, a variety of biological and pharmaceutical treatments, targeting scar modulation, have been tested in animal models of CNS injury, and a few are likely to enter clinical trials. In this review, we summarize current knowledge of the scar-modulating treatments according to their specific aims:(1) inhibition of glial and fibrotic scar formation, and(2) blockade of the production of scar-associated inhibitory molecules. The removal of existing scar tissue is also discussed as a treatment of choice. It is believed that only a combinatorial strategy is likely to help eliminate the detrimental effects of scar tissue on CNS repair. 关键词：中枢神经系统损伤药物治疗疤痕成年哺乳动物 CNS 细胞反应动物模型临床试验

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Scar-modulating treatments for central nervous system injury

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