Contribution of epigenetics in diabetic retinopathy

查看全文 作　　者：KOWLURU Renu [1]A.;MISHRA [1]Manish

机构地区：[1]Kresge Eye Institute, Wayne State University

出　　处：《Science China(Life Sciences)》索引2015年第58卷第6期,共8页

摘　　要：Diabetes has become the epidemic of the 21 st century, and with over 90% patients with diabetes becoming at a risk of developing retinopathy, diabetic retinopathy has emerged as a major public health concern. In spite of cutting edge research in the field, how retina and its vasculature are damaged by the diabetic milieu remains ambiguous. The environmental factors, life style or disease process can also bring in modifications in the DNA, and these epigenetic modifications either silence or activate a gene without altering the DNA sequence. Diabetic environment up- or downregulates a number of genes in the retina, and emerging research has shown that it also facilitates epigenetic modifications. In the pathogenesis of diabetic retinopathy, the genes associated with important enzymes(e.g., mitochondrial superoxide dismutase, matrix metalloproteinase-9 and thioredoxin interacting protein) and transcriptional factors are epigenetically modified, the enzymes responsible for these epigenetic modifications are either activated or inhibited, and the levels of micro RNAs are altered. With epigenetic modifications taking an important place in diabetic retinopathy, it is now becoming critical to evaluate these modifications, and understand their impact on this slow progressing blinding disease. 关键词：糖尿病视网膜病变表观遗传学基质金属蛋白酶-9 超氧化物歧化酶遗传修饰 DNA序列公共卫生问题环境因素

相关文献

参考文献（93）
引证文献（13）
耦合文献（13）

参考文献(93)

引证文献(13)

耦合文献(13)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Contribution of epigenetics in diabetic retinopathy

参考文献(93)

引证文献(13)

耦合文献(13)

用户提示