A comparative study of preventing postoperative tendon adhesion using electrospun polyester membranes with different degradation kinetics

查看全文 作　　者：Zhiming [1]Song;Bo [2,3,4]Shi;Jianxun [2,3,5]Ding;Xiuli [2,3,5]Zhuang;Xiaonan [1]Zhang;Changfeng [4]Fu;Xuesi [2,3,5]Chen

机构地区：[1]Department of Sports Medicine,First Hospital of Jilin University;[2]Key Laboratory of Polymer Ecomaterials;[3]Changchun Institute of Applied Chemistry,Chinese Academy of Sciences;[4]Department of Spine Surgery,First Hospital of Jilin University;[5]Changchun Sino Biomaterials Co.,Ltd.

出　　处：《Science China Chemistry》索引2015年第58卷第7期,共10页

基　　金：financially supported by the National Natural Science Foundation of China(51303174,51473165,51233004,51390484,51273196,51321062,51203153);the Scientific Development Program of Jilin Province(20140520050JH) 摘　　要：Complications arising from tendon injury include tendon sheath infection and peritendinous adhesion, in which tendon adhesion often leads to serious motor dysfunction. In this work, the electrospun membranes of poly(L-lactide)(PLA) and poly(ε-caprolactone)(PCL) with different degradation kinetics were used to investigate their efficacy for anti-adhesion toward Achilles tendon repair. Compared with the PCL membrane, the PLA sample showed a faster rate of degradation in 42 d, and all the degradation media(i.e., phosphate-buffered saline) maintained at a constant p H of around 7.4. Meanwhile, the superior biocompatibility of both the PLA and PCL membranes were proved by the in vitro cellular adhesion tests and in vivo histopathological assays. Simultaneously, the PLA membrane was more effective than the PCL sample in decreasing adhesion and promoting functional recovery. Furthermore, the experiment result was further confirmed by hematoxylin-eosin and Masson's trichrome staining, and type I collagen immunohistochemical analysis. All results revealed that the model treated with the electrospun PLA membrane was obviously better with regard to both anti-adhesion and tendon repair than that in the PCL membrane group. Considering the results of degradation and adhesion prevention efficacy, the electrospun polyester membranes, especially the PLA one, would be applied with fascinating potential in clinical prevention of postoperative tendon adhesion. 关键词：降解动力学抗粘连肌腱 L膜静电预防涤纶 PCL

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A comparative study of preventing postoperative tendon adhesion using electrospun polyester membranes with different degradation kinetics

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