The Hedgehog signalling pathway in bone formation

查看全文 作　　者：Jing [1,2]Yang;Philipp [2]Andre;Ling [1]Ye;Ying-Zi [2,3]Yang

机构地区：[1]State Key Laboratory of Oral Diseases,West China Hospital of Stomatology,Sichuan University;[2]Genetic Disease Research,National Human Genome Research Institute,National Institutes of Health;[3]Harvard School of Dental Medicine

出　　处：《International Journal of Oral Science》索引2015年第7卷第2期,共7页

基　　金：supported by an intramural research programme,NHGRI,National Institutes of Health(NIH);the National Science Foundation for Excellent Young Scholars of China(grant no.813220170);the Innovation Team of Sichuan Province(2015TD0011);the China Scholarship Council 摘　　要：The Hedgehog(Hh) signalling pathway plays many important roles in development,homeostasis and tumorigenesis.The critical function of Hh signalling in bone formation has been identified in the past two decades.Here,we review the evolutionariiy conserved Hh signalling mechanisms with an emphasis on the functions of the Hh signalling pathway in bone development,homeostasis and diseases.In the early stages of embryonic limb development,Sonic Hedgehog(Shh) acts as a major morphogen in patterning the limb buds.Indian Hedgehog(Ihh) has an essential function in endochondral ossification and induces osteoblast differentiation in the perichondrium.Hh signalling is also involved intramembrane ossification.Interactions between Hh and Wnt signalling regulate cartilage development,endochondral bone formation and synovial joint formation.Hh also plays an important role in bone homeostasis,and reducing Hh signalling protects against age-related bone loss.Disruption of Hh signalling regulation leads to multiple bone diseases,such as progressive osseous heteroplasia.Therefore,understanding the signalling mechanisms and functions of Hh signalling in bone development,homeostasis and diseases will provide important insights into bone disease prevention,diagnoses and therapeutics. 关键词：Wnt信号通路骨形成刺猬成骨细胞分化 HEDGEHOG 软骨发育信号机制骨疾病

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The Hedgehog signalling pathway in bone formation

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