Blood-brain barrier modeling: challenges and perspectives

查看全文 作　　者：Tobias [1]Ruck;Stefan [1]Bittner;Sven [1]G.Meuth

机构地区：[1]Department of Neurology,University of Münster

出　　处：《Neural Regeneration Research》索引2015年第10卷第6期,共3页

基　　金：supported by Innovative Medizinische Forschung(I-RU211405 to TR and I-BI111316 to SB and SGM);by the Deutsche Forschungsgemeinschaft(SFB 1009);by the Genzyme Neuroimmunology Fellowship Program(to TR) 摘　　要：The blood-brain barrier(BBB)forms a highly selective interface between blood and brain.Extensive research efforts have completely changed our view of the BBB in the last years,from a static,impermeable barrier to a dynamic,highly regulated and specific cellular system.The BBB ultrastructurally consists of specialized brain microvascular endothelial cells(BMEC)characterized by low pinocytic activity,absent fenestrations and expression of specific and polarized transcellular transport systems.BMECs are interconnected by protein complexes consisting of tight and adherens junctions leading to high electrical resistance and low paracellular permeability.Attached 关键词：血脑屏障脑微血管内皮细胞展望模型蜂窝系统超微结构脑组织血液

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Blood-brain barrier modeling: challenges and perspectives

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