In vivo gastric mucosal histopathology using endocytoscopy

查看全文 作　　者：Hiroki [1]Sato;Haruhiro [1]Inoue;Haruo [1]Ikeda;Chiaki [1]Sato;Chainarong [1]Phlanusittepha;Bu'Hussain [2]Hayee;Esperanza Grace R [3]Santi;Yasutoshi [4]Kobayashi;Shin-ei [1]Kudo

机构地区：[1]Digestive Disease Center,Showa University,Northern Yokohama Hospital;[2]Department of Gastroenterology,King’s College Hospital NHS Foundation Trust,London SE5 9RS,United Kingdom;[3]Department of Gastroenterology,De La Salle University Medical Center;[4]Kobayashi Internal Medicine Clinic

出　　处：《World Journal of Gastroenterology》索引2015年第21卷第16期,共7页

摘　　要：AIM:To study the ability of endocytoscopy to identify normal gastric mucosa and to exclude Helicobacter pylori(H.pylori) infection.METHODS:Endocytoscopic examination of the gastric corpus and antrum was performed in 70 consecutive patients.Target biopsy specimens were also obtained from the assessed region and multiple H.pylori tests were performed.The normal endocytoscopy patterns of the corpus and antrum were divided into the normal pit-dominant type(n-Pit) or the normal papilladominant type(n-Pap), respectively characterized as either regular pits with capillary networks or round, smooth papillary structures with spiral capillaries.On the other hand, normal mucosa was defined as mucosa not demonstrating histological abnormalities, including inflammation and atrophy.RESULTS:The sensitivity and specificity of n-Pit for normal mucosa in the gastric corpus were 94.4%and 97.1%,respectively,whereas those of n-Pap for normal mucosa in the antrum were 92.0%and 86.7%,respectively.The positive predictive values of n-Pit and n-Pap for H.pylori-negative tissue were 88.6%and 93.1%,respectively,and their negative predictive values for H.pylori-negative tissues were 42.9%and41.5%,respectively.The inter-observer agreement for determining n-Pit and n-Pap for normal mucosa were0.857 and 0.769,respectively,which is considered reliable.CONCLUSION:N-Pit and n-Pap,seen using EC,are considered useful predictors of normal mucosa and theabsence of H.pylori infection. 关键词：ATROPHY ENDOCYTOSCOPY Gastric MUCOSA HELICOBACTER PYLORI In vivo HISTOPATHOLOGY

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In vivo gastric mucosal histopathology using endocytoscopy

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