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Immunomodulation of enteric neural function in irritable bowel syndrome

查看全文 作　　者：Dervla O'[1]Malley 高影响力作者 机构地区：[1]Department of Physiology and Alimentary Pharmabiotic Centre,University College Cork,Cork,Ireland高影响力机构 出　　处：《World Journal of Gastroenterology》索引2015年第21卷第24期,共5页高影响力期刊 摘　　要：Irritable bowel syndrome(IBS) is a common functional gastrointestinal disorder which is characterised by symptoms such as bloating, altered bowel habit and visceral pain. It's generally accepted that miscommunication between the brain and gut underlies the changes in motility, absorpto-secretory functionand pain sensitivity associated with IBS. However, partly due to the lack of disease-defining biomarkers, understanding the aetiology of this complex and multifactorial disease remains elusive. Anecdotally, IBS patients have noted that periods of stress can result in symptom flares and many patients exhibit comorbid stress-related mood disorders such as anxiety and depression. However, in addition to psychosocial stressors, infection-related stress has also been linked with the initiation, persistence and severity of symptom flares. Indeed, prior gastrointestinal infection is one of the strongest predictors of developing IBS. Despite a lack of overt morphological inflammation, the importance of immune factors in the pathophysiology of IBS is gaining acceptance. Subtle changes in the numbers of mucosal immune cell infiltrates and elevated levels of circulating pro-inflammatory cytokines have been reproducibly demonstrated in IBS populations. Moreover, these immune mediators directly affect neural signalling. An exciting new area of research is the role of luminal microbiota in the modulation of neuro-immune signalling, resulting in local changes in gastrointestinal function and alterations in central neural functioning. Progress in this area has begun to unravel some of the complexities of neuroimmune and neuroendocrine interactions and how these molecular exchanges contribute to GI 关 键 词：NEUROIMMUNE IRRITABLE bowel syndrome Interleukin MYENTERIC SUBMUCOSAL Microbiota
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