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Role of peroxisome proliferator-activated receptors gene polymorphisms in type 2 diabetes and metabolic syndrome

查看全文 作　　者：Chen [1]Dong;Hui [1,2]Zhou;Chong [3]Shen;Lu-Gang [2]Yu;Yi [2]Ding;Yong-Hong [1]Zhang;Zhi-Rong [1]Guo 高影响力作者 机构地区：[1]Department of Epidemiology,School of Public Health,Soochow University;[2]Suzhou Industrial Park Centers for Disease Control and Prevention;[3]Department of Epidemiology and Biostatistics,School of Public Health,Nanjing Medical University高影响力机构 出　　处：《World Journal of Diabetes》索引2015年第6卷第4期,共8页高影响力期刊 摘　　要：Metabolic syndrome(MetS) and type 2 diabetes mellitus(T2DM) are the serious public health problems worldwide.Moreover,it is estimated that MetS patients have about five-fold greater risk of the T2 DM development compared with people without the syndrome.Peroxisome proliferator-activated receptors are a subgroup of the nuclear hormone receptor superfamily of ligand-activated transcription factors which play an important role in the pathogenesis of MetS and T2 DM.All three members of the peroxisome proliferator-activated receptor(PPAR) nuclear receptor subfamily,PPARα,PPARp/5 and PPARγ are critical in regulating insulin sensitivity,adipogenesis,lipid metabolism,and blood pressure.Recently,more and more studies indicated that the gene polymorphism of PPARs,such as Leu^(162)Val and Val^(227)Ala of PPARα,+294T> C of PPARβ/δ,Pro^(12)Ala and C1431 T of PPARγ,are significantly associated with the onset and progressing of MetS and T2 DM in different population worldwide.Furthermore,a large body of evidence demonstrated that the glucose metabolism and lipid metabolism were influenced by gene-gene interaction among PPARs genes.However,given the complexity pathogenesis of metabolic disease,it is unlikely that genetic variation of a single locus would provide an adequate explanation of inter-individual differences which results in diverse clinical syndromes.Thus,gene-gene interactions and gene-environment interactions associated with T2 DM and MetS need future comprehensive studies. 关 键 词：POLYMORPHISMS METABOLIC syndrome Type2 diabetes MELLITUS PEROXISOME proliferator-activatedreceptors
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