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Functions of Müller cell-derived vascular endothelial growth factor in diabetic retinopathy

查看全文 作　　者：Juan-Juan [1,2]Wang;Meili [1]Zhu;Yun-Zheng [1,3,4,5]Le 高影响力作者 机构地区：[1]Department of Medicine Endocrinology,University of Oklahoma Health Sciences Center;[2]Department of Ophthalmology,Huizhou Municipal Central Hospital;[3]Department of Cell Biology,University of Oklahoma Health Sciences Center;[4]Department of Ophthalmology,University of Oklahoma Health Sciences Center;[5]Harold Hamm Diabetes Center,University of Oklahoma Health Sciences Center高影响力机构 出　　处：《World Journal of Diabetes》索引2015年第6卷第5期,共8页高影响力期刊 基　　金：Supported by The NIH grants,Nos.GM104934,EY020900 and EY021725(NEI Core);Chinese National Natural Science Foundation grant,No.81200699;grants from Presbyterian Health Foundation and Oklahoma Center for Adult Stem Cell Research and an endowment from Choctaw Nation(to Le YZ) 摘　　要：Müller cells are macroglia and play many essential roles as supporting cells in the retina.To respond to pathological changes in diabetic retinopathy(DR),a major complication in the eye of diabetic patients,retinal Müller glia produce a high level of vascular endothelial growth factor(VEGF or VEGF-A).As VEGF is expressed by multiple retinal cell-types and Müller glia comprise only a small portion of cells in the retina,it has been a great challenge to reveal the function of VEGF or other globally expressed proteins produced by Müller cells.With the development of conditional gene targeting tools,it is now possible to dissect the function of Müller cell-derived VEGF in vivo.By using conditional gene targeting approach,we demonstrate that Müller glia are a major source of retinal VEGF in diabetic mice and Müller cell-derived VEGF plays a significant role in the alteration of protein expression and peroxynitration,which leads to retinal inflammation,neovascularization,vascular leakage,and vascular lesion,key pathological changes in DR.Therefore,Müller glia are a potential cellular target for the treatment of DR,a leading cause of blindness. 关 键 词：Müller GLIA Vascular ENDOTHELIAL growthfactor Protein modification Inflammation Blood-retinabarriers DIABETIC RETINOPATHY
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