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Model for end-stage liver disease-Na score or Maddrey discrimination function index, which score is best?

查看全文 作  者:Mercedes Amieva-[1]Balmori;Scherezada María Isabel Mejia-[1]Loza;Roberto Ramos-[1]González;Felipe Zamarripa-[1]Dorsey;Eli García-[1]Ruiz;Nuria Pérez y [1]López;Eumir I Juárez-[1]Valdés;Adriana López-[1]Luria;José María Remes-[2]Troche 高影响力作者 机构地区:[1]Servicio de Gastroenterología, Instituto de Investigaciones Médico-Biológicas de la Universidad Veracruzana,Hospital Juárez de México;[2]Laboratorio de Fisiología Digestiva, Instituto de Investigaciones Médico-Biológicas de la Universidad Veracruzana高影响力机构 出  处:《World Journal of Hepatology》索引2015年第7卷第17期,共8页高影响力期刊 摘  要:AIM: To compare the ability of model for end-stage liver disease(MELD)-Na and Maddrey discrimination function index(DFI) to predict mortality at 30 and 90 d in patients with alcoholic hepatitis(AH).METHODS: We prospectively assessed 52 patients with AH. Demographic, clinical and laboratory parameters were obtained. MELD-Na and Maddrey DFI were calculated on admission. Short-term mortality was assessed at 30 and 90 d. Receiver operating characteristic curve analysis was performed. RESULTS: Thirty-day and 90-d mortality was 44% and 58%, respectively. In the univariate analysis, sodium levels was associated with mortality at 30 and 90 d(P = 0.001 and P = 0.03). Child stage, encephalopathy, ascites, or types of treatment were not associated with mortality. MELD-Na was the only predictive factor for mortality at 90 d. For 30-d mortality area under the curve(AUC) was 0.763(95%CI: 0.63-0.89) for Maddrey DFI and 0.784 for MELD-Na(95%CI: 0.65-0.91, P = 0.82). For 90-d mortality AUC was 0.685(95%CI: 0.54-0.83) for Maddrey DFI and 0.8710 for MELD-Na(95%CI: 0.76-0.97, P = 0.041). CONCLUSION: AH is associated with high shortterm mortality. Our results show that MELD-Na is a more valuable model than DFI to predict short-term mortality. 关 键 词:ALCOHOLIC HEPATITIS Model for end-stageliver disease-Na Maddrey Mortality
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