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Impact of adjuvant treatment modalities on survival outcomes in curatively resected pancreatic and periampullary adenocarcinoma

查看全文 作　　者：Nedim [1]Turan;Mustafa [2]Benekli;Olcun Umit [3]Unal;?lkay Tugba [3]Unek;Didem [4]Tastekin;Faysal [5]Dane;Efnan Alg?[2]n;Sukran [6]Ulger;Tulay [7]Eren;Turkan Ozturk [8]Topcu;Esma [9]Turkmen;Nalan Akgül [1]Babacan;Gulnihal [10]Tufan;Zuhat [11]Urakci;Basak Oven [12]Ustaalioglu;Ozlem Sonmez [13]Uysal;Ozlem Balvan [12]Ercelep;Burcu Yapar [14]Taskoylu;Asude [15]Aksoy;Mustafa [16]Canhoroz;Umut [17]Demirci;Erkan [18]Dogan;Veli [19]Berk;Ozan [20]Balakan;Ahmet ?iyar [21]Ekinci;Mukremin [22]Uysal;?brahim [23]Petekkaya;Sel?uk Cemil [24]Ozturk;?nder Tonyal?[25];Bülent ?[2]etin;Mehmet Naci [26]Aldemir;Kaan Helvac?[17];Nuriye [7]Ozdemir;?lhan [3]Oztop;Ugur [2]Coskun;Aytug [2]Uner;Ahmet [2]Ozet;Suleyman [2]Buyukberber 高影响力作者 机构地区：[1]Department of Medical Oncology, Faculty of Medicine, Cumhuriyet University;[2]Department of Medical Oncology, Faculty of Medicine, Gazi University;[3]Department of Medical Oncology, Faculty of Medicine, Dokuz Eylul University;[4]Department of Medical Oncology, Faculty of Medicine, Necmettin Erbakan University;[5]Department of Medical Oncology, Faculty of Medicine, Marmara University;[6]Department of Radiation Oncology, Faculty of Medicine, Gazi University;[7]Department of Medical Oncology, Numune Education and Research Hospital;[8]Department of Medical Oncology, Faculty of Medicine, Karadeniz Technical University;[9]Department of Medical Oncology, Faculty of Medicine, Trakya University;[10]Department of Medical Oncology, Rize Education and Research Hospital;[11]Department of Medical Oncology, Faculty of Medicine, Dicle University;[12]Department of Medical Oncology, Dr.Lutfi Kirdar Kartal Education and Research Hospital;[13]Department of Medical Oncology, Sakarya Education and Research Hospital;[14]Department of Medical Oncology, Faculty of Medicine, Pamukkale University;[15]Department of Medical Oncology, Faculty of Medicine, Inonu University;[16]Department of Medical Oncology, Faculty of Medicine, Firat University;[17]Department of Medical Oncology, Dr.Abdurrahman Yurtaslan Education and Research Hospital;[18]Department of Medical Oncology, Faculty of Medicine, Yuzuncu Yil University;[19]Department of Medical Oncology, Faculty of Medicine, Erciyes University;[20]Department of Medical Oncology, Faculty of Medicine, Sutcu Imam University;[21]Department of Medical Oncology, Diyarbakir Education and Research Hospital;[22]Department of Medical Oncology, Faculty of Medicine, Kocatepe University;[23]Department of Medical Oncology, Dr.Ersin Arslan State Hospital;[24]Department of Medical Oncology, Education and Research Hospital, Ad?yaman University;[25]Department of Medical Oncology, Faculty of Medicine, Mustafa Kemal University;[26]Department of Medical Oncology, Faculty of Medicine, Ataturk University高影响力机构 出　　处：《Chinese Journal of Cancer Research》索引2015年第27卷第4期,共9页高影响力期刊 摘　　要：Background: We examined the impact of adjuvant modalities on resected pancreatic and periampullary adenocarcinoma(PAC).Methods: A total of 563 patients who were curatively resected for PAC were retrospectively analyzed between 2003 and 2013.Results: Of 563 patients, 472 received adjuvant chemotherapy(CT) alone, chemoradiotherapy(CRT) alone, and chemoradiotherapy plus chemotherapy(CRT-CT) were analyzed. Of the 472 patients, 231 were given CRT-CT, 26 were given CRT, and 215 were given CT. The median recurrence-free survival(RFS) and overall survival(OS) were 12 and 19 months, respectively. When CT and CRT-CT groups were compared, there was no significant difference with respect to both RFS and OS, and also there was no difference in RFS and OS among CRT-CT, CT and CRT groups. To further investigate the impact of radiation on subgroups, patients were stratified according to lymph node status and resection margins. In node-positive patients, both RFS and OS were significantly longer in CRT-CT than CT. In contrast, there was no significant differencebetween groups when patients with node-negative disease or patients with or without positive surgical margins were considered.Conclusions: Addition of radiation to CT has a survival benefit in patients with node-positive disease following pancreatic resection. 关 键 词：胰腺 治疗方式 预后 癌 RFS 淋巴结 CRT 辅助疗法
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