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Comparative analysis between endometrial proteomes of pregnant and non-pregnant ewes during the peri-implantation period

查看全文 作　　者：Haichao [1]Zhao;Linlin [1,2]Sui;Kai [1]Miao;Lei [1]An;Dong [3]Wang;Zhuocheng [4]Hou;Rui [1]Wang;Min [1]Guo;Zhilong [1]Wang;Jiqiang [5]Xu;Zhonghong [6]Wu;Jianhui [1]Tian 高影响力作者 机构地区：[1]Ministry of Agriculture Key Laboratory of Animal Genetics,Breeding and Reproduction,National engineering laboratory for animal breeding,College of Animal Sciences and Technology,China Agricultural University;[2]Department of Biochemistry and Molecular,Dalian Medical University;[3]The Key Laboratory for Farm Animal Genetic Resources and Utilization of Ministry of Agriculture of China,Institute of Animal Science,Chinese Academy of Agriculture Sciences;[4]National Engineering Laboratory for Animal Breeding and MOA Key Laboratory of Animal Genetics and Breeding,China Agricultural University;[5]College of Animal Science and Technology,Agricultural University of Hebei;[6]State Key Laboratory of Animal Nutrition,College of Animal Sciences and Technology,China Agricultural University高影响力机构 出　　处：《Journal of Animal Science and Biotechnology》索引2015年第6卷第3期,共14页高影响力期刊 基　　金：supported by grants from the National High-Tech R&D Program (Nos.2011AA100303,2013AA102506);the National Key Technology R&D Program(Nos.2011BAD19B01,2011BAD19B03,2011BAD19B04) 摘　　要：Background:Early pregnancy failure has a profound impact on both human reproductive health and animal production.2/3 pregnancy failures occur during the peri-implantation period;however,the underlying mechanism(s)remains unclear.Well-organized modification of the endometrium to a receptive state is critical to establish pregnancy.Aberrant endometrial modification during implantation is thought to be largely responsible for early pregnancy loss.Result:In this study,using well-managed recipient ewes that received embryo transfer as model,we compared the endometrial proteome between pregnant and non-pregnant ewes during implantation period.After embryo transfer,recipients were assigned as pregnant or non-pregnant ewes according to the presence or absence of an elongated conceptus at Day 17 of pregnancy.By comparing the endometrial proteomic profiles between pregnant and non-pregnant ewes,we identified 94 and 257 differentially expressed proteins(DEPs) in the endometrial caruncular and intercaruncular areas,respectively.Functional analysis showed that the DEPs were mainly associated with immune response,nutrient transport and utilization,as well as proteasome-mediated proteolysis.Conclusion:These analysis imply that dysfunction of these biological processes or pathways of DEP in the endometrium is highly associated with early pregnancy loss.In addition,many proteins that are essential for the establishment of pregnancy showed dysregulation in the endometrium of non-pregnant ewes.These proteins,as potential candidates,may contribute to early pregnancy loss. 关 键 词：妊娠母羊 子宫内膜 蛋白质组 植入 早期妊娠 妊娠失败 胚胎移植 动物生产
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