Neuroinflammation and comorbidities are frequently ignored factors in CNS pathology

查看全文 作　　者：Raluca Elena [1]Sandu;Ana Maria [2,1]Buga;Adriana [2,3]Uzoni;Eugen Bogdan [4]Petcu;Aurel Popa-[2,1]Wagner

机构地区：[1]Center of Clinical and Experimental Research, University of Medicine and Pharmacy Craiova;[2]Department of Psychiatry, University of Medicine Rostock;[3]Biochemistry Department, University of Medicine and Pharmacy 'Victor Babes' Timisoara;[4]Griffith University School of Medicine, Regenerative Medicine Centre

出　　处：《Neural Regeneration Research》索引2015年第10卷第9期,共7页

基　　金：supported by a POSDRU grant no.159/1.5/S/136893 grant:'Strategic partnership for the increase of the scientific research quality in medical universities through the award of doctoral and postdoctoral fellowships–Doc Med.Net_2.0' 摘　　要：Virtually all drug interventions that have been successful pre-clinically in experimental stroke have failed to prove their efficacy in a clinical setting. This could be partly explained by the complexity and heterogeneity of human diseases as well as the associated co-morbidities which may render neuroprotective drugs less efficacious in clinical practice. One aspect of crucial importance in the physiopathology of stroke which is not completely understood is neuroinflammation. At the present time, it is becoming evident that subtle, but continuous neuroinflammation can provide the ground for disorders such as cerebral small vessel disease. Moreover, advanced aging and a number of highly prevalent risk factors such as obesity, hypertension, diabetes and atherosclerosis could act as 'silent contributors' promoting a chronic proinflammatory state. This could aggravate the outcome of various pathological entities and can contribute to a number of subsequent post-stroke complications such as dementia, depression and neurodegeneration creating a pathological vicious cycle. Moreover, recent data suggests that the inflammatory process might be closely linked with multiple neurodegenerative pathways related to depression. In addition, pro-inflammatory cytokines could play a central role in the pathophysiology of both depression and dementia. 关键词：中枢神经系统人类疾病炎症反应病理因素神经退行性疾病老年痴呆症临床疗效动脉粥样硬化

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Neuroinflammation and comorbidities are frequently ignored factors in CNS pathology

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