Multi-scale modeling of hemodynamics in the cardiovascular system

查看全文 作　　者：Hao [1,2]Liu;Fuyou [2]Liang;Jasmin [3]Wong;Takashi [1]Fujiwara;Wenjing [3]Ye;Ken-iti [1]Tsubota;Michiko [1]Sugawara

机构地区：[1]Graduate School of Engineering, Chiba University;[2]Shanghai Jiao Tong University and Chiba University International Cooperative Research Center (SJTU-CU ICRC);[3]The Hong Kong University of Science and Technology(HKUST)

出　　处：《Acta Mechanica Sinica》索引2015年第31卷第4期,共19页

基　　金：supported by Grant-in-Aid for Scientifi Research(Grant(B)17300141);the Development and Use of the Next Generation Supercomputer Project of the MEXT,Japan;Fuyou Liang was supported by the National Natural Science Foundation of China(Grant 81370438);the SJTU Medical Engineering Cross-cutting Research Foundation(Grant YG2012MS24);Ken-iti Tsubota was partly funded by a Grant-in-Aid for Challenging Exploratory Research(Grant 25630046),JSPS;supporting the computing facilities essential for the completion of this study;Financial support provided by HKUST to JW is acknowledged 摘　　要：The human cardiovascular system is a closedloop and complex vascular network with multi-scaled heterogeneous hemodynamic phenomena. Here, we give a selective review of recent progress in macro-hemodynamic modeling, with a focus on geometrical multi-scale modeling of the vascular network, micro-hemodynamic modeling of microcirculation, as well as blood cellular, subcellular,endothelial biomechanics, and their interaction with arterial vessel mechanics. We describe in detail the methodology of hemodynamic modeling and its potential applications in cardiovascular research and clinical practice. In addition,we present major topics for future study: recent progress of patient-specifi hemodynamic modeling in clinical applications, micro-hemodynamic modeling in capillaries and blood cells, and the importance and potential of the multi-scale hemodynamic modeling. 关键词：血流动力学心血管系统多尺度建模动力学模型临床应用多尺度模型血细胞力学现象

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Multi-scale modeling of hemodynamics in the cardiovascular system

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