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Low skeletal muscle mass is associated with non-alcoholic fatty liver disease in Korean adults: the Fifth Korea National Health and Nutrition Examination Survey

查看全文 作　　者：hee yeon [1]kim;chang wook [1]kim;chung-hwa [1]park;jong young [1]choi;kyungdo [2]han;anwar t [3]merchant;yong-moon [4]park 高影响力作者 机构地区：[1]division of hepatology,department of internal medicine,college of medicine,the catholic university of korea,222,Banpo-daero,Seocho-gu,Seou1 06591,Republic of Korea;[2]department of biostatistics,college of medicine,the catholic university of korea,222,Banpo-daero,Seocho-gu,Seou1 06591,Republic of Korea;[3]department of epidemiology and biostatistics,arnold school of public health,university of south carolina,Columbia,SC 29208,USA;[4]epidemiology branch,national institute of environmental health sciences,national institutes of health,department of health and human services,Research Triangle Park,NC 27709,USA高影响力机构 出　　处：《Hepatobiliary & Pancreatic Diseases International》索引2016年第15卷第1期,共9页高影响力期刊 摘　　要：BACKGROUND: Sarcopenia and non-alcoholic fatty liver disease(NAFLD) share similar pathophysiological mechanisms, and the relationship between sarcopenia and NAFLD has been recently investigated. The study investigated whether low skeletal muscle mass is differentially associated with NAFLD by gender in Korean adults.METHODS: We conducted a cross-sectional analysis of the data from the Fifth Korea National Health and Nutrition Examination Survey. The skeletal muscle index(SMI) was obtained by the appendicular skeletal muscle mass divided by the weight. NAFLD was defined as a fatty liver index(FLI) ≥60 in the absence of other chronic liver disease.RESULTS: Among the included subjects, 18.3%(SE: 1.4%) in men and 7.0%(SE: 0.7%) in women were classified as having FLI-defined NAFLD. Most of the risk factors for FLI-defined NAFLD showed a significant negative correlation with the SMI in both genders. Multiple logistic regression analysis showed that low SMI was associated with FLI-defined NAFLD, independent of other metabolic and lifestyle parameters in both genders [males: odds ratio(OR)=1.35; 95% confidence interval(CI): 1.17-1.54; females: OR=1.36; 95% CI: 1.18-1.55]. The magnitude of the association between FLI-defined NAFLD and low SMI was higher in middle aged to elderly males(OR=1.50; 95% CI: 1.22-1.84) than in males less than 45 years of age(OR=1.25; 95% CI: 1.02-1.52) and in premenopausal females(OR=1.50; 95% CI: 1.12-2.03) than in postmenopausal females(OR=1.36; 95% CI: 1.20-1.54).CONCLUSIONS: Low SMI is associated with the risk of FLIdefined NAFLD independent of other well-known metabolic risk factors in both genders. This association may differ according to age group or menopausal status. Further studies are warranted to confirm this relationship. 关 键 词：脂肪肝病 质量差异 酒精性 骨骼肌 韩国 Logistic回归分析 检查 营养
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