Molecular genetics and targeted therapeutics in biliary tractcarcinoma

查看全文 作　　者：Eric I [1]Marks;Nelson S [2,3]Yee

机构地区：[1]Department of Medicine,Penn State Milton S.Hershey Medical Center,Hershey,PA 17033,United States;[2]Division of Hematology-Oncology,Department of Medicine,Penn State Hershey Medical Center,Hershey,PA 17033,United States;[3]Program of Experimental Therapeutics,Penn State Hershey Cancer Institute,Hershey,PA 17033,United States

出　　处：《World Journal of Gastroenterology》索引2016年第22卷第4期,共13页

摘　　要：The primary malignancies of the biliary tract, cholangio-carcinoma and gallbladder cancer, often present at an advanced stage and are marginally sensitive to radiation and chemotherapy. Accumulating evidence indicates that molecularly targeted agents may provide new hope for improving treatment response in biliary tract carcinoma(BTC). In this article, we provide a critical review of the pathogenesis and genetic abnormalities of biliary tract neoplasms, in addition to discussing the current and emerging targeted therapeutics in BTC. Genetic studies of biliary tumors have identified the growth factors and receptors as well as their downstream signaling pathways that control the growth and survival of biliary epithelia. Target-specific monoclonal antibodies and small molecules inhibitors directed against the signaling pathways that drive BTC growth and invasion have been developed. Numerous clinical trials designed to test these agents as either monotherapy or in combination with conventional chemotherapy have been completed or are currently underway. Research focusing on understanding the molecular basis of biliary tumorigenesis will continue to identify for targeted therapy the key mutations that drive growth and invasion of biliary neoplasms. Additional strategies that have emerged for treating this malignant disease include targeting the epigenetic alterations of BTC and immunotherapy. By integrating targeted therapy with molecular profiles of biliary tumor, we hope to provide precision treatment for patients with malignant diseases of the biliary tract. 关键词：BILIARY TRACT CARCINOMA CHOLANGIOCARCINOMA GALLBLADDER CARCINOMA Molecular genetics Personalizedtreatment Precision THERAPY Targeted THERAPY

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Molecular genetics and targeted therapeutics in biliary tractcarcinoma

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耦合文献(31)

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