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Glutathione S-transferase M1 polymorphism and esophagealcancer risk:An updated meta-analysis based on 37 studies

查看全文 作　　者：Quan-Jun [1]Lu;Ya-Cong [1]Bo;Yan [2]Zhao;Er-Jiang [3]Zhao;Wolde Bekalo [1]Sapa;Ming-Jie [4]Yao;Dan-Dan [1]Duan;Yi-Wei [1]Zhu;Wei-Quan [3]Lu;Ling [5]Yuan 高影响力作者 机构地区：[1]Department of Nutrition and Food Hygiene,College of Public Health,Zhengzhou University,Zhengzhou 450001,Henan Province,China;[2]Department of Epidemiology and Biostatistics,College of Public Health,Zhengzhou University,Zhengzhou 450001,Henan Province,China;[3]Affiliated Tumor Hospital of Zhengzhou University,Henan Tumor Hospital,Zhengzhou 450003,Henan Province,China;[4]School of Basic Medical Sciences,Peking University,Beijing 100191,China;[5]Department of Radiotherapy,Affiliated Tumor Hospital of Zhengzhou University,Henan Tumor Hospital,Zhengzhou 450003,Henan Province,China高影响力机构 出　　处：《World Journal of Gastroenterology》索引2016年第22卷第5期,共8页高影响力期刊 基　　金：Supported by Science and Technology Project of The Health Department of Henan Province;China;No.510102050432 摘　　要：AIM: To evaluate the relationship between glutathione S-transferase M1(GSTM1) polymorphism and susceptibility to esophageal cancer(EC).METHODS: A comprehensive search of the United States National Library of Medicine Pub Med database and the Elsevier, Springer, and China National Knowledge Infrastructure databases for all relevant studies was conducted using combinations of the following terms: 'glutathione S-transferase M1', 'GSTM1', 'polymorphism', and 'EC'(until November 1, 2014). The statistical analysis was performed using the SAS software(v.9.1.3; SAS Institute, Cary, NC, United States) and the Review Manager software(v.5.0; Oxford, England); crude odds ratios(ORs) with 95% confidence intervals(CIs) were used to assess the association between the GSTM1 null genotype and the risk of EC.RESULTS: A total of 37 studies involving 2236 EC cases and 3243 controls were included in this metaanalysis. We observed that the GSTM1 null genotype was a significant risk factor for EC in most populations(OR = 1.33, 95%CI: 1.12-1.57, P_(heterogeneity) < 0.000001, and I2 = 77.0%), particularly in the Asian population(OR = 1.53, 95%CI: 1.26-1.86, P_(heterogeneity)< 0.000001, and I2 = 77.0%), but not in the Caucasian population(OR = 1.02, 95%CI: 0.87-1.19, P_(heterogeneity) = 0.97, and I2 = 0%).CONCLUSION: The GSTM1 null polymorphism may be associated with an increased risk for EC in Asian but not Caucasian populations. 关 键 词：META-ANALYSIS GLUTATHIONE S-transferaseM1 POLYMORPHISM ESOPHAGEAL cancer DELETIONS
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